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Improved cancer immunotherapies require radical CAR overhaul
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Improved cancer immunotherapies require radical CAR overhaul

by Johannes Angerer, Medical University of Vienna CAR-T cell therapy is a new and revolutionary weapon against cancer: T cells are isolated from the patient’s blood for genetic modification and then infused back into the patient to attack cancer cells. Researchers from the Medical University of Vienna have now determined why CAR-T cells do not...

Phosphorus: Glowing, Flammable, and Essential to Our Cells
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Phosphorus: Glowing, Flammable, and Essential to Our Cells

BY ABBEY BIGLER Of the 118 known elements, scientists believe that 25 are essential for human biology. Four of these (hydrogen, oxygen, nitrogen, and carbon) make up a whopping 96 percent of our bodies. The other 21 elements, though needed in smaller quantities, perform fascinating and vital functions. Phosphorus is one such element. It has...

40% of virus carriers in Italian town show no symptoms: study
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40% of virus carriers in Italian town show no symptoms: study

More than 40 percent of people diagnosed with COVID-19 in one Italian town showed no signs of being ill, according to research published Tuesday indicating that asymptomatic carriers may be significant spreaders of the virus. The authors said their research showed how important mass testing and isolating carriers was in containing clusters of the virus....

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Sniffing out smell

ew study reveals how the brain organizes information about odors HARVARD MEDICAL SCHOOL The premiere of the movie Scent of Mystery in 1960 marked a singular event in the annals of cinema: the first, and last, motion picture debut “in glorious Smell-O-Vision.” Hoping to wow moviegoers with a dynamic olfactory experience alongside the familiar spectacles...

How the immune system generates a vast antibody repertoire to fight infections
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How the immune system generates a vast antibody repertoire to fight infections

by Research Institute of Molecular Pathology It has long been known that the acquired immune system can generate a vast antibody (immunoglobulin) repertoire by gene recombination in developing B-cells. However, it was not understood how the different immunoglobulin gene segments can meet each other in the three-dimensional space of a B-cell nucleus to undergo recombination,...

Researchers find on-off switch for inflammation related to overeating
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Researchers find on-off switch for inflammation related to overeating

by Brita Belli, Yale University Researchers at Yale have identified a molecule that plays a key role in the body’s inflammatory response to overeating, which can lead to obesity, diabetes, and other metabolic diseases. The finding suggests that the molecule could be a promising therapeutic target to control this inflammation and keep metabolic diseases in...

Existing drugs can prevent SARS-CoV-2 from hijacking cells
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Existing drugs can prevent SARS-CoV-2 from hijacking cells

by European Molecular Biology Laboratory An international team of researchers has analyzed how SARS-CoV-2, the virus that causes COVID-19, hijacks the proteins in its target cells. The research, published in the journal Cell, shows how the virus shifts the cell’s activity to promote its own replication and to infect nearby cells. The scientists also identified...

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How cancer drugs find their targets

In the watery inside of a cell, complex processes take place in tiny functional compartments called organelles. Energy-producing mitochondria are organelles, as is the frilly golgi apparatus, which helps to transport cellular materials. Both of these compartments are bound by thin membranes. But in the past few years, research at Whitehead Institute and elsewhere has...

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Designer peptides show potential for blocking viruses, encourage future study

Research demonstrates how Rensselaer-made peptides can bind to cells and potentially block viruses Designer peptides show potential for blocking viruses, e TROY, N.Y. — Chemically engineered peptides, designed and developed by a team of researchers at Rensselaer Polytechnic Institute, could prove valuable in the battle against some of the most persistent human health challenges. The...