Peer-Reviewed Publication TAMPERE UNIVERSITY SCHEMATIC DIAGRAM HIGHLIGHTING PROPOSED MECHANISM OF ACTION OF CAR PEPTIDE. SYSTEMICALLY ADMINISTERED CAR PEPTIDE ASSOCIATES WITH THE HSPG SDC4, WHICH IS RESTRICTED TO EPIDERMIS AND BLOOD VESSELS IN MOUSE SKIN WOUNDS. CAR INDUCES SDC4-DEPENDENT ACTIVATION OF THE SMALL GTPASE ARF6, VIA THE GUANINE NUCLEOTIDE EXCHANGE FACTOR CYTH2, TO PROMOTE SDC4-, ARF6-...
Peer-Reviewed Publication YALE UNIVERSITY New Haven, Conn. — Treatment with a molecule known as A485 can quickly and temporarily increase levels of white blood cells, a critical part of the body’s immune system, an effect that is difficult to deliver with currently available pharmaceuticals, a new Yale study finds. In an experiment, the researchers found...
OREGON HEALTH & SCIENCE UNIVERSITY IMAGE: TIANYI MAO, PH.D., AT LEFT, AND HAINING ZHONG, PH.D., SCIENTISTS WITH THE VOLLUM INSTITUTE AT OREGON HEALTH & SCIENCE UNIVERSITY, LED A NEW STUDY FINDING THAT ADENOSINE EFFECTIVELY ACTS AS A BRAKE TO DOPAMINE IN THE BRAIN. CREDIT: OREGON HEALTH & SCIENCE UNIVERSITY Researchers at Oregon Health & Science...
by Kelly Malcom, University of Michigan Chronic liver disease is associated with NIK upregulation in cholangiocytes. A, B Human liver sections were stained with antibodies to NIK and K19. A Representative images. Scale bar: 200 μm. B NIK+, K19+, and NIK+K19+ cells were counted and normalized to total cells. Control: n = 3 subjects, PBC: n = 3 subjects, PSC: n = 3 subjects, HBV: n = 5 subjects, HCV: n = 3 subjects, Alcohol: n = 3 subjects. C, D C57BL/6J male mice were...
UNIVERSITY OF BONN IMAGE: HUMAN BROWN ADIPOCYTES, LIPID STAINED RED (REDO OIL STAIN) CREDIT: © LAIA REVERTE SALISA / UNIVERSITY OF BONN Normally, fat cells store energy. In brown fat cells, however, energy is dissipated as heat – brown fat thus serves as a biological heater. Most mammals therefore have this mechanism. In humans it...
by Roswell Park Comprehensive Cancer Center Credit: Pixabay/CC0 Public Domain A research team led by scientists at Roswell Park Comprehensive Cancer Center has discovered a molecule that inhibits the growth and metastasis of pancreatic cancer cells through the iron metabolism pathway. Their findings, recently published in Molecular Cancer Therapeutics, pave the way toward the development of...
JANUARY 14, 2022 by Ludwig Maximilian University of Munich Immunofluorescence image of lung tissue showing co-localization of TRPML3 (green) and macrophages (red). Credit: Barbara Spix Chronic obstructive pulmonary disease—COPD for short—is one of the most common diseases of the lung. It affects almost 300 million people worldwide, of which about three million die every year. A...
In a randomized control study of 10 healthy young men, researchers compared how consuming the single amino acid leucine or its two-molecule equivalent, dileucine, influenced muscle-building and breakdown. They found that dileucine boosts the metabolic processes that drive muscle growth 42% more than free leucine does. They reported their findings in the Journal of Applied...
by University of North Carolina Health Care Credit: CC0 Public Domain Many molecules in our bodies help our immune system keep us healthy without overreacting so much that our immune cells cause problems, such as autoimmune diseases. One molecule, called AIM2, is part of our innate immunity—a defense system established since birth—to fight pathogens and keep...
