by Justin Jackson , Medical Xpress Inhibition of authentic SARS-CoV-2 infection by human anti-hACE2 mAbs. a,b, Anti-hACE2 mAbs (2G7A1, 05H02, 05B04 and the hybrid antibody 05B04LC/05D06HC) were serially diluted and incubated with Vero E6 and Huh-7.5 target cells (a) or Vero E6 target cells only (b). Thereafter, cells were infected with authentic SARS-CoV-2 (WA1/2020) (a...
Tag: <span>Monoclonal antibodies</span>
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Experimental monoclonal antibodies can coax aggressive prostate and breast cancers into submission, finds research
by Delthia Ricks, Medical Xpress Therapeutic inhibition of VEGF binding to NRP2 activates anti-tumor immunity in a syngeneic model of prostate cancer that is resistant to aPD-L1 therapy. (A) Shown is quantification of tumor volume in C57BL/6J mice injected with TRAMP-C2 cells and treated with either IgG control or aPD-L1 antibody. Error bars represent SEM....
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The dark side of treating COVID-19 with monoclonal antibodies
by CORDIS Credit: Pixabay/CC0 Public Domain A recent study conducted as part of the ORCHESTRA project has shed new light on the treatment of COVID-19 infections with mAbs. Published in the Journal of Clinical Investigation, the research reveals that patients treated with different mAbs may develop SARS-CoV-2 mutations in certain cases. The scientists developed a score that identifies...
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How monoclonal antibodies lost the fight with new COVID variants
PIEN HUANG Antonio Rapuano got an infusion of a monoclonal antibody to treat his COVID in Albano, Italy in 2021. Such infusions have been effective treatments for COVID during the pandemic, but doctors are now finding that most monoclonal antibodies no longer work against new variants of SARS-CoV-2. Yara Nardi/Reuters Monoclonal antibodies were once the...
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Monoclonal antibodies preserve stem cells in mouse brains, bring promise for future studies
MICHIGAN MEDICINE – UNIVERSITY OF MICHIGAN A new approach to stem cell therapy that uses antibodies instead of traditional immunosuppressant drugs robustly preserves cells in mouse brains and has potential to fast-track trials in humans, a Michigan Medicine study suggests. For this study, researchers used monoclonal antibodies to suppress the immune system in mice and...
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Monoclonal antibodies remain effective against latest SARS-CoV-2 variants
by The Francis Crick Institute Credit: Pixabay/CC0 Public Domain Monoclonal antibody therapies continue to neutralize SARS-CoV-2 variants currently in circulation, including omicron BA.4/5, according to laboratory findings from the Francis Crick Institute and the National Institute for Health Research (NIHR) UCLH Biomedical Research Center, published as a research letter in The Lancet. In the U.K., monoclonal antibodies are part of an important strategy to protect clinically...
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Could monoclonal antibodies replace opioids for chronic pain?
by UC Davis A model of a complex protein that may fit into nerve channels and stop the transmission of pain. Credit: Phuong Tran Nguyen, UC Davis During the pandemic, physicians used infusions of monoclonal antibodies—antibodies made in a lab—to help patients fight off COVID-19 infections. Now, researchers at UC Davis are trying to create...
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COVID antibody drugs work best when given as early as possible
Ewen Callaway A tray holds supplies for administering monoclonal antibodies to treat COVID-19.Credit: Kayana Szymczak/Bloomberg/Getty A first-of-its-kind analysis has a clear message about when to give the COVID-19 therapies called monoclonal antibodies: the earlier people get this type of treatment, the better they fare1. The study, based on dozens of clinical trials, also suggests that...
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Those at highest risk for severe COVID-19 often least likely to get monoclonal antibodies
by Harvard T.H. Chan School of Public Health Credit: Pixabay/CC0 Public Domain People over age 65 at the highest risk for severe COVID-19 have often been the least likely to receive monoclonal antibodies (mAbs)—a highly effective treatment for the disease—both across and within U.S. states, according to new research co-authored by researchers from Harvard T.H....
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Omicron resistant to most monoclonal antibodies but neutralized by a booster dose
by Pasteur Institute 3D visualization of mutations in the spike protein of the Omicron variant. Left: overhead view. Right: lateral view. Mutations are indicated in red. They occur all over the spike protein but particularly in the receptor binding domain (RBD) and in the region known as the N-terminal domain (NTD). Credit: Institut Pasteur –...
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