by Will Cushman, University of Wisconsin-Madison A section of brain tissue from a rat that received a gene therapy targeting the Trk-fused gene. A mutation in that gene is implicated in the development of certain motor neuron diseases. Green arrows highlight neurons expressing elevated levels of the gene following the therapy. Red arrows indicate other nerve...
Tag: <span>motor neuron</span>
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Researchers discover elevated spinal cord enzyme linked to motor neuron aging
by Justin Jackson , Medical Xpress Credit: CC0 Public Domain A research collaboration led by the University of Chinese Academy of Sciences, China, investigated the role of CHIT1, a protein associated with microglia, in aging. In a paper, “CHIT1-positive microglia drive motor neuron aging in the primate spinal cord,” published in Nature, the group identifies...
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Antiepileptic drug reduces motor neuron excitability in ALS
MASSACHUSETTS GENERAL HOSPITAL BOSTON – The antiepileptic drug ezogabine reduced pathologic excitability of cortical and spinal motor neuron cells that are early signs of clinical dysfunction in people with amyotrophic lateral sclerosis (ALS), according to a study conducted by the Neurological Clinical Research Institute of Massachusetts General Hospital (MGH). In addition to providing a clearer understanding of...