UNIVERSITÄT LEIPZIG IMAGE: THE IMAGE SERIES SHOWS CROSS-SECTIONAL ELECTRON MICROGRAPHS OF INDIVIDUAL NERVE FIBERS IN MS BRAIN BIOPSIES. AXONS SHEATHED WITH MYELIN (BLACK RINGS) CAN BE SEEN, SHOWING INCREASINGLY SEVERE DAMAGE FROM 1 TO 8. THE SPECTRUM RANGES FROM ACCUMULATION OF INDIVIDUAL CELLULAR COMPONENTS IN OTHERWISE STILL BRIGHT, INTACT AXONS (1) TO ADVANCED DEGENERATION IN...
Nancy A. Melville June 14, 2023 In the ongoing absence of a reliable biomarker for multiple sclerosis (MS), misdiagnosis is a common, and persistent, problem that potentially puts patients at prolonged and unnecessary risk. Experts warn that false-negative diagnoses cause treatment delays, while false-positive diagnoses run the risk for potential harm from needless treatment. Dr Patricia Coyle “MS has...
by University of California, San Francisco Credit: CC0 Public Domain A decade after UC San Francisco scientists identified an over-the-counter antihistamine as a treatment for multiple sclerosis, researchers have developed an approach to measure the drug’s effectiveness in repairing the brain, making it possible to also assess future therapies for the devastating disorder. The researchers, led by physician-scientist Ari...
by Linköping University Credit: CC0 Public Domain Women suffering from the autoimmune disease multiple sclerosis temporarily get much better when pregnant. Researchers have now identified the beneficial changes naturally occurring in the immune system during pregnancy. The findings, published in Journal of Neuroinflammation, may pave the way to new treatments. Pregnancy is a very special condition from an immunological...
by University of Virginia Loss of FOXP3 expression in DDX39B-depleted T cells. (A) RNA abundance changes between control (NTC) and DDX39B-depleted (Sh3) CD4+ T cells from two healthy individuals (Donor 1 and Donor 4) identified by RNAseq. Data points for DDX39B (cyan) and FOXP3 (magenta) are indicated. (B) Examples of MS susceptibility genes differentially expressed upon DDX39B...
Interview conducted by Danielle Ellis, B.Sc. May 30 2023 Thought LeadersDr. Cameron McAlpine Assistant Professor of Medicine and NeuroscienceIcahn School of Medicine at Mount Sinai To commemorate World Multiple Sclerosis (MS) Day, we spoke to Dr. Cameron McAlpine, an Assistant Professor of Medicine and Neuroscience at the Icahn School of Medicine at Mount Sina, about his latest research that sought to understand...
by Carmen Rotte, Max Planck Society Inflammation occurring in the normal-appearing white matter. (A) Luxol Fast Blue, (B) proteolipid protein, and (C) Kim1p stainings of the optic nerve shows no demyelination or reactive sites, other than from some nodules, with a scale bar of 400nm. (D) Amyloid precursor protein (APP)+ axonal fragments (E) were found in both...
by Karolinska Institutet Credit: Pixabay/CC0 Public Domain Researchers at Karolinska Institutet in Sweden have found further evidence for how the Epstein-Barr virus can trigger multiple sclerosis or drive disease progression. A new study published in Science Advances shows that some individuals have antibodies against the virus that mistakenly attack a protein in the brain and spinal cord. The Epstein-Barr...
MAY 2ND, 2023 CONN HASTINGS MEDICINE Researchers at the Harvard Wyss Institute have developed a new type of cell therapy for multiple sclerosis patients. The technique involves taking a blood sample from the patient being treated, isolating a sample of myeloid white blood cells, and then modifying them with ‘backpacks’ that contain anti-inflammatory molecules. The modified cells...
by Kessler Foundation Credit: Pixabay/CC0 Public Domain Results of a pilot study have shown that remote aerobic walking exercise training is a feasible and highly promising method for improving cognitive processing speed impairment in fully ambulatory persons with multiple sclerosis (MS). The findings of this single-blind randomized control trial support the design of a randomized,...
