by Michele Santillan, University of Michigan College of Engineering Skeletal muscle fibers. Credit: Berkshire Community College Bioscience Image Library / Public domainA team of researchers led by Carlos Aguilar, an associate professor of biomedical engineering at the University of Michigan, and graduate students Jesus Castor-Macias and Jacqueline Larouche, has sought to address how lipid mediators, which...
by Kobe University Fig. 1. Left: Method of inducing mild muscle injury. While under anesthetic, the protractor muscle in the animal’s hind leg is exposed and then clamped by forceps with a 250g weight attached. Right: The muscle injuries induced using this method affect around 4% of total myofibers. C Shows that this method enables mild...
By WYSS INSTITUTE FOR BIOLOGICALLY INSPIRED ENGINEERING AT HARVARD OCTOBER 6, 2021 Study in mice confirms link between mechanotherapy and immunotherapy in muscle regeneration. Massage has been used to treat sore, injured muscles for more than 3,000 years, and today many athletes swear by massage guns to rehabilitate their bodies. But other than making people feel good,...
by Hong Kong University of Science and Technology Fig. 1: Discordant proteomic and transcriptomic signatures reveal a potential translational control mechanism during the SC quiescence-to-activation transition. a Schematic illustration of the workflow for the proteomic analysis of FACS-isolated SCs. The SCs were sorted from Pax7-nGFP mice. QSCs were sorted from 0.5% PFA-perfused mice. fiSCs were...
by Perelman School of Medicine at the University of Pennsylvania An image of a control cell with normal muscle regeneration compared to a cell with the same genetic mutation that people with FOP have. Credit: Penn Medicine Fibrodysplasia ossificans progressiva (FOP) is a rare disease characterized by extensive bone growth outside of the normal skeleton...
Senescent cells accumulate with age. Researchers here provide evidence for yet another age-related decline to be added to the long list of issues in which this accumulation of senescent cells is an important contributing cause. In this case, the problem is the loss of regenerative capacity in muscle tissue that occurs with age. Can this...
Saint Louis University researchers report in Molecular Metabolism new findings that the nuclear receptor REV-ERB appears to play a key role in muscle regeneration, suggesting the receptor may be a good target for new drugs to treat a variety of muscle disorders and injuries. Colin Flaveny, Ph.D. assistant professor of pharmacology and physiology and Thomas Burris, Ph.D.,...
