by Wellcome Trust Sanger Institute Experimental design overview. a Two independent sgRNAs and associated HDR variant libraries are designed at the 5′ and 3′ end of each exon. b The sgRNA, together with the HDR template library are transfected into LIG4-KO Cas9-expressing HAP1 cells. HDR utilizes the library as a template for repair of the sgRNA-directed...
Genetic analysis of psoriasis shows somatic mutations are not linked to the development or the spread of the condition.Peer-Reviewed Publication WELLCOME TRUST SANGER INSTITUTE Psoriasis — a chronic skin condition — is not caused or spread by spontaneous genetic mutations in the skin, new research suggests. The team, from the Wellcome Sanger Institute and collaborators,...
Ralph Ellis September 26, 2023 The antiviral COVID medication made by Merck can cause mutations in the coronavirus that occasionally spread to other people, according to a study published in the online journal Nature. There’s no evidence that molnupiravir, sold under the brand name Lagevrio, has caused the creation of more transmissible or severe variants of COVID,...
by Brigham and Women’s Hospital Graphical abstract. Credit: Cell Genomics (2023). DOI: 10.1016/j.xgen.2023.100327 Less than two percent of the human genome codes for proteins, with the rest being noncoding and likely helping with gene regulation. Mutations in the noncoding genome often trigger trait changes that cause disease or disability by altering gene expression. However, it can be hard...
by Anne Trafton, Massachusetts Institute of Technology A new study shows that when the gene Foxp2 is knocked out in mouse striatal neurons (top right panel), the protein dynactin (stained red) and the chain that binds dynactin and dynein (stained green) show abnormal spacing compared to wildtype neurons (top left panel). This suggests that the functions...
by Emily Boynton, University of Rochester Medical Center Graphical abstract. Credit: Molecular Cell (2023). DOI: 10.1016/j.molcel.2023.01.009 Scientists have discovered a new way to suppress mutations that lead to a wide range of genetic disorders. A study recently published in the journal Molecular Cell describes a strategy that co-opts a normal RNA modification process within cells to transform disease genes into normal genes that produce...
Anne Trafton | MIT News Office Publication Date: June 20, 2022 Caption: An MIT-led team has built a new system that rapidly scans the genome of cancer cells, could help researchers find targets for new drugs. Credits: Image: Dylan Burnette and Jennifer Lippincott-Schwartz, National Institutes of Health, edited by MIT News Cancer cells can have...
by Weizmann Institute of Science Credit: CC0 Public Domain Genetic mutations linked to a disease often spell bad news. Mutations in over 25 genes, for example, are associated with amyotrophic lateral sclerosis, or ALS, and they all increase the risk of developing this incurable disorder. Now, a research team headed by Prof. Eran Hornstein of...
by Tom Ulrich, Broad Institute of MIT and Harvard Credit: DOI: 10.1038/s41587-021-01160-7 There are millions of mutations and other genetic variations in cancer. Understanding which of these mutations is an impactful tumor “driver” compared to an innocuous “passenger,” and what each of the drivers does to the cancer cell, however, has been a challenging undertaking....
Credit: Pixabay/CC0 Public Domain Scientists in South Africa said Thursday they had detected a new COVID-19 variant with a large number of mutations, blaming it for a surge in infection numbers. The number of daily infections in Africa’s hardest-hit country has increased tenfold since the start of the month. “Unfortunately we have detected a new...
