Genetically driven MDS enabled by gene linked to metabolism and oxygen in cells CINCINNATI CHILDREN’S HOSPITAL MEDICAL CENTER CINCINNATI – Scientists may be on the road to solving the mystery of a group of mostly incurable blood diseases called myelodysplastic syndromes (MDS), which cause people to have immature, malfunctioning bone marrow cells that fuel a...
Tag: <span>Mutations</span>
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Chinese scientists test CRISPR on monkeys and find no off-target mutations
With the first UK and US human trials using the potentially revolutionary CRISPR gene editing technique about to commence, several questions still hover over the ultimate safety of this system. A team of Chinese scientists has now conducted the first full assessment of the effects of CRISPR-Cas9 on non-human primates to ascertain whether it results...
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Erdafitinib shows promise in urothelial cancer patients with specific mutations
MD Anderson-led Phase II trial suggests FGFR inhibitor may benefit patients when immunotherapy fails UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER CHICAGO – In an international Phase II trial led by researchers at The University of Texas MD Anderson Cancer Center, treatment with the oral FGFR inhibitor erdafitinib (ERDA) was well-tolerated and achieved a...
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Largest-ever study of thyroid cancer genetics finds new mutations, suggests immunotherapy
University of Colorado Cancer Center researchers recently completed the largest-ever study of thyroid cancer genetics, mining the data of 583 patient samples of advanced differentiated thyroid cancer and 196 anaplastic thyroid cancers. In addition to the identification of specific genes that may drive these cancers and thus provide attractive targets for treatment, the researchers found that in several samples...
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Loss-of-Function KIF5A Mutations Linked to Amyotrophic Lateral Sclerosis
NEW YORK (GenomeWeb) – Researchers have linked loss-of-function mutations in the KIF5A gene to amyotrophic lateral sclerosis. ALS, also known as Lou Gehrig’s disease, is a progressive neurodegenerative disease that affects about 14,500 people in the US, according to the Centers for Disease Control and Prevention. An international team of researchers led by John Lander...