MIT researchers find that in mice and human cell cultures, lipid nanoparticles can deliver a potential therapy for inflammation in the brain, a prominent symptom in Alzheimer’s.Some Covid-19 vaccines safely and effectively used lipid nanoparticles (LNPs) to deliver messenger RNA to cells. A new MIT study shows that different nanoparticles could be used for a...
Tag: <span>nanoparticle</span>
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Scientists create nanoparticle that helps fight solid tumors
by Wake Forest University Baptist Medical Center Design and characterization of NP700-ARL. (A) Scheme illustration of the self-assembly of NP700-ARL. In this delivery system, (1) the photosensitizer-containing lipid polymer DSPE-PEG-IR700 is a “ROS-producing” component, which damages tumor cells and induces ATP release under light irradiation; at the same time, it produces ROS as stimuli to...
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A nanoparticle and inhibitor trigger the immune system, outsmarting brain cancer
MICHIGAN MEDICINE – UNIVERSITY OF MICHIGAN IMAGE: GLIOMA CELLS CREDIT: UNIVERSITY OF MICHIGAN ROGEL CANCER CENTER ANN ARBOR, Michigan — Scientists at the University of Michigan Rogel Cancer Center were optimistic when they identified a small molecule that blocked a key pathway in brain tumors. But there was a problem: How to get the inhibitor...
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Nanoparticle reduces skin and lung scarring for scleroderma, mouse study finds
The findings provide promise of targeted treatment for patients with the disease. Investigators have discovered that a biodegradable nanoparticle used in medical sutures could combat a rare, sometimes-fatal autoimmune disease. Researchers found that a unique macrophage, an immune cell that removes bacteria or dead cells, plays a key role in the chronic inflammation and scarring...
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Clearing cholesterol crystals with a new nanoparticle
An innovative nanoparticle could one day help address an untreatable risk factor for heart attacks and strokes: cholesterol crystals that trigger inflammation and evade medications. “Although lipid-lowering drugs substantially prevent cardiovascular events in atherosclerosis, some patients still suffer from high residual risk because the existing cholesterol crystals in the atherosclerotic plaques activate immune cells and...
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Nanoparticle therapeutic enhances cancer immunotherapy
WAKE FOREST BAPTIST MEDICAL CENTER IMAGE: DAWEN ZHAO, M.D., PH.D., ASSOCIATE PROFESSOR OF BIOMEDICAL ENGINEERING AT WAKE FOREST SCHOOL OF MEDICINE, AND TEAM HAVE DISCOVERED THAT A NANOPARTICLE THERAPEUTIC ENHANCES CANCER IMMUNOTHERAPY AND IS A POSSIBLE NEW APPROACH IN TREATING MALIGNANT PLEURAL EFFUSION (MPE). CREDIT: WAKE FOREST SCHOOL OF MEDICINE WINSTON-SALEM, N.C. – Dec. 16,...
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Nanoparticle drug delivery technique shows promise for treating pancreatic cancer
VETERANS AFFAIRS RESEARCH COMMUNICATIONS IMAGE: STUDY RESEARCHERS DRS. SNIGDHA BANERJEE, SUMAN KAMBHAMPATI, SUSHANTA BANERJEE, AND A COLLEAGUE EXAMINE A PANCREATIC CANCER IMAGE. CREDIT: JEFF GATES Researchers with the Kansas City Veterans Affairs Medical Center and North Dakota State University have designed a new way to deliver pancreatic cancer drugs that could make fighting the disease much easier. Encapsulating...
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Nanoparticle drug-delivery system developed to treat brain disorders
by Brigham and Women’s Hospital Credit: Pixabay/CC0 Public Domain In the past few decades, researchers have identified biological pathways leading to neurodegenerative diseases and developed promising molecular agents to target them. However, the translation of these findings into clinically approved treatments has progressed at a much slower rate, in part because of the challenges scientists face in delivering...
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Nanoparticle chomps away plaques that cause heart attacks
Michigan State University and Stanford University scientists have invented a nanoparticle that eats away – from the inside out – portions of plaques that cause heart attacks. Bryan Smith, associate professor of biomedical engineering at MSU, and a team of scientists created a “Trojan Horse” nanoparticle that can be directed to eat debris, reducing and...
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NTU Singapore scientists devise ‘Trojan horse’ approach to kill cancer cells without using drugs
NANYANG TECHNOLOGICAL UNIVERSITY IMAGE: (LEFT TO RIGHT) MEMBERS OF THE NTU RESEARCH TEAM INCLUDE ASSISTANT PROFESSOR DALTON TAY FROM THE SCHOOL OF MATERIALS SCIENCE AND ENGINEERING, RESEARCH ASSOCIATE KENNY WU AND ASSOCIATE PROFESSOR TAN NGUAN SOON FROM NTU’S LEE KONG CHIAN SCHOOL OF MEDICINE. Cancer cells are killed in lab experiments and tumour growth reduced...
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