by Delthia Ricks, Medical Xpress Antibody-mediated NK cell activity in children: (A) Merozoite opsonizing antibodies from Junju adults (n=40) induced a significantly higher proportion of ab-NK cells degranulation compared to Junju children (n=293). Hyperimmune (PHIS) and malaria naive plasma were included as positive and negative controls, respectively. Error bars represent a 95% confidence interval of...
by Albert Einstein College of Medicine Left shows the tumor-cell protein PVR binding with the NK-cell receptor KIR2DL5 to prevent NK-cell attack. Right, monoclonal antibody short-circuits tumor cell/NK cell interaction, allowing the NK cell to attack and destroy the tumor cell. Credit: Tatyana Harris/Albert Einstein College of Medicine Immune checkpoint inhibitors such as Keytruda and...
by Delthia Ricks , Medical Xpress PD-1 dependent NK cell regulation of CD8+T-cells. C57BL/6 mice were infected with an adenoviral vector encoding the HBV genome and treated with anti-NK1.1 (⍺NK) or isotype control antibody prior to therapeutic vaccination. Intrahepatic lymphocytes were harvested 14 days after immunization. (A) Quantitative real-time PCR analysis of HBsAg mRNA extracted...
by Massachusetts General Hospital New research from Massachusetts General Hospital explains how natural killer (NK) cells’ interactions with extracellular matrix proteins regulate their function in solid organs, findings that could yield major therapeutic implications for cancer, viral infection, autoimmunity, and other inflammatory diseases. Here, NK cells (green) are embedded in collagen (red) rich matrix of...
Natural killer cells do not just kill cancer cells or cells infected with viruses, they also mediate a trade-off between wound healing and bacterial defense in skin wounds. If the healing process is accelerated, the immune defense is weakened, researchers at the University of Zurich have now shown. This has relevance in treating skin injuries and in...
An impaired count of natural killer (NK) immune cells and reduced ability to destroy infected cells are key characteristics of severe COVID-19 infection, according to newly published research in the journal Blood Advances. A team of researchers at the University of Alberta and University of Calgary followed 12 patients with severe COVID-19 symptoms at hospitals in Edmonton. They found that the...
by Johannes Angerer, Medical University of Vienna Good news for the human immune system: Researchers from MedUni Vienna’s Departments of Dermatology and Surgery have managed to ascribe an immunological memory function to a subset of cytotoxic NK cells, which have hitherto been regarded as antigen-non-specific. Under the leadership of Georg Stary, the researchers found that around...
