by Amy Huxtable, University of Sheffield Production of isopeptide-bonded BoNT molecules.(A) Schematic of the structural organization of BoNT/A (upper panel) with additions of the SpyCatcher elements to two botulinum parts (lower panel). (B) Coomassie-stained SDS–PAGE showing the purified proteins and spontaneous assembly of isopeptide-bonded BoNT. (C) Coomassie-stained SDS–PAGE showing isolation of iBoNT from the unreacted excess...
In animal models of a totally crushed peripheral nerve, the damaged axons are broken down, allowing healthy ones to regrow. But humans rarely suffer complete axonal damage. Instead, axons tend to be partially damaged, causing neuropathic pain — a difficult-to-treat, chronic pain associated with nerve trauma, chemotherapy and diabetes. A new study in Cell, led...
Spinal injuries can be like downed power lines – even if everything on either side of the injury is perfectly functional, the break can effectively shut down the whole system. Now, researchers at the University of Minnesota have designed a device that could link everything back together again. A silicone guide, covered in 3D-printed neuronal stem cells,...
