Scientists from the University of Birmingham have shown that a brain-penetrating candidate drug currently in development as a cancer therapy can foster regeneration of damaged nerves after spinal trauma. The research, published today in Clinical and Translational Medicine, used cell and animal models to demonstrate that when taken orally the candidate drug, known as AZD1390, can...
Tag: <span>Nerve Repair</span>
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Research shows investigational drug fosters nerve repair after injury
by University of Birmingham Credit: Unsplash/CC0 Public Domain Scientists from the University of Birmingham have shown that a brain-penetrating candidate drug currently in development as a cancer therapy can foster regeneration of damaged nerves after spinal trauma. The research, published today in Clinical and Translational Medicine, used cell and animal models to demonstrate that when taken orally...
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What regulates the ‘glue’ needed for nerve repair?
by University of Queensland Injured axons of the nematode C. elegans and other invertebrate species are able to rejoin with their separated segments, preventing degeneration and restoring the original axonal tract in a process known as axonal fusion. Ho et al. identify a metalloprotease of the ADAM family, ADM-4, as a key component necessary for...
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Nerve repair, with help from stem cells
A new approach to repairing peripheral nerves marries the regenerating power of gingiva-derived mesenchymal stem cells with a biological scaffold to enable the functional recovery of nerves following a facial injury, according to a study by a cross-disciplinary team from the University of Pennsylvania School of Dental Medicine and Perelman School of Medicine. Faced with...
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Researchers Apply Microvesicle Technology for Nerve Repair
Nerve injury is a common clinical problem. The repair or regeneration of the defective nerve is a complex process. Peripheral nerves have a limited capacity to regenerate after an injury. Microvesicles are a type of extracellular vesicles that are released from the cell membrane. The membranes of mesenchymal stem cells, for instance. Recent studies have...