BEN-GURION UNIVERSITY OF THE NEGEV BEER-SHEVA, Israel, January 13, 2022 – A green Mediterranean diet, high in polyphenols and low in red and processed meat, seems to slow age-related brain atrophy, according to a new Ben-Gurion University of the Negev-led international study. The DIRECT PLUS 18-month long randomized control trial among ~300 participants is one...
Tag: <span>neurodegeneration</span>
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Scientists identify gut-derived metabolites that play a role in neurodegeneration
by CUNY Advanced Science Research Center A new study has identified gut-derived metabolites that appear to be neurotoxic and play a role in the progression of multiple sclerosis. Credit: Nicoletta Barolini A New York-based, multi-institutional research team has found high levels of three toxic metabolites produced by gut bacteria in the cerebrospinal fluid and plasma samples...
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The Age-Related Decline of Energy Metabolism in Myeloid Cells as an Important Cause of Neurodegeneration
Today’s open access editorial discusses one quite specific consequence of the age-related disruption of energy metabolism in cells. Mitochondria, the power plants of the cell, falter with age throughout the body, for complex reasons still under exploration. The proximate causes involve too little production of molecular machinery needed for the correct operation of the electron transport chain, or mitochondrial dynamics,...
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Fat cells found to play a central role in cognitive decline and neurodegeneration
by Marshall University Joan C. Edwards School of Medicine Credit: Pixabay/CC0 Public Domain Findings published this week reveal new insights into the role of fat cells in cognitive decline and neurodegeneration, according to a study that involves the oxidant amplification loop led by Marshall University scientists. The research, published in iScience, shows that fat cells control...
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Complicating the Contribution of Persistent Infection to Neurodegeneration and Alzheimer’s Disease Risk
Researchers have in recent years put forward contradictory evidence for and against a role for persistent infection, such as by herpesviruses, in neurodegeneration and the incidence of Alzheimer’s disease. The Alzheimer’s disease scientific community is in need of a good explanation as to why only some people with the known risk factors go on to develop the condition. That disease...
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“phase separation” allows an RNA to tightly control the activity of a protein that regulates neurodegeneration and aging
UT SOUTHWESTERN MEDICAL CENTER IMAGE: IMAGE SHOWS CELLS WITH OIL DROPLET-LIKE ‘NORAD-PUMILIO BODIES’ IN RED AND NUCLEUS IN BLUE. CREDIT: MAHMOUD ELGUINDY CREDIT: MAHMOUD ELGUINDY DALLAS – June 9, 2021 – A phenomenon in which an RNA named NORAD drives a protein named Pumilio to form liquid droplets in cells, much like oil in water,...
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Simple blood test can accurately reveal underlying neurodegeneration
by King’s College London Credit: CC0 Public Domain A new study of over 3000 people led by King’s College London in collaboration with Lund University, has shown for the first time that a single biomarker can accurately indicate the presence of underlying neurodegeneration in people with cognitive issues. Levels of a protein called neurofilament light chain...
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Researchers describe a molecular mechanism involved in the pathology’s neurodegeneration
UNIVERSITY OF BARCELONA IMAGE: FROM LEFT TO RIGHT: CARLA CASTANY-PLADEVALL, ESTHER PÉREZ-NAVARRO AND ARANTXA GOLBANO. CREDIT: UNIVERSITY OF BARCELONA Protein alteration in the family of lamins causes several diseases, known as laminopathies, such as progeria or precocious ageing. A study in which UB researchers have taken part states that alterations in the levels of one of these...
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New class of highly effective inhibitors protects against neurodegeneration
by Heidelberg University Neurobiologists at Heidelberg University have discovered how a special receptor at neuronal junctions that normally activates a protective genetic program can lead to nerve cell death when located outside synapses. Their fundamental findings on neurodegenerative processes simultaneously led the researchers at the Interdisciplinary Center for Neurosciences (IZN) to a completely new principle for therapeutic agents....
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Microglia might lessen seizure severity in epilepsy
by American Physiological Society New research in mice highlights the potential protective effect of microglia—a type of non-neuronal cell in the brain—against overactivation of the central nervous system during acute epileptic seizures. The study is published in the American Journal of Physiology-Cell Physiology. Epilepsy is a brain disorder in which the electrical activity of the...