by Bob Yirka, Medical Xpress CDMCs are morphologically and functionally similar but distinct from microglia. (A) Representative images of Iba-1+ cells in the cortex of untransplanted mice (−), mice after BMT + P (12 weeks after transplantation), and mice after BMT + P (24 weeks after transplantation). The bottom panels are enlarged images of the...
by Columbia University A key fragment of the protein TMEM106B, several atomic models of which are shown here, can stack into single or twinned types of fibrils. Credit: Andrew Chang and Anthony Fitzpatrick / Columbia University’s Zuckerman Institute / Cell Take a cell-deep tour of a brain afflicted with Alzheimer’s disease, and you will find minuscule...
by The Francis Crick Institute A depiction of the double helical structure of DNA. Its four coding units (A, T, C, G) are color-coded in pink, orange, purple and yellow. Credit: NHGRI Researchers at the Francis Crick Institute have pieced together genetic and molecular changes that lead to a rare progressive neurodegenerative condition called ataxia...
BUCK INSTITUTE FOR RESEARCH ON AGING IMAGE: TAU INTERACTOME MAPS SYNAPTIC AND MITOCHONDRIAL PROCESSES ASSOCIATED WITH NEURODEGENERATION CREDIT: THE BUCK INSTITUTE FOR RESEARCH ON AGING Utilizing cutting-edge proteomics, researchers at the Buck Institute and elsewhere have mapped the “tau interactome” uncovering new findings about the role of tau in neurodegenerative disease. Publishing in Cell, scientists found that...
by Göttingen University The image shows neuronal cell nuclei of the dentus gyratus (yellow) and associated blood vessels (red). By varying the magnification of the X-ray optics, one can “zoom in” on the densely packed band of neurons (in the red oval) and also resolve the substructure of the cell nucleus (blue oval). The study...
ROCKEFELLER UNIVERSITY PRESS IMAGE: COMPARED WITH A NORMAL CELL (LEFT), AN OLIGODENDROCYTE LACKING TDP-43 (CENTER) PRODUCES LESS MYELIN (GREEN) BECAUSE IT IS UNABLE TO SYNTHESIZE OR TAKE UP SUFFICIENT AMOUNTS OF CHOLESTEROL. SUPPLEMENTING TDP-43–DEFICIENT CELLS WITH CHOLESTEROL (RIGHT) RESTORES MYELIN PRODUCTION. CREDIT: ©2021 HO ET AL. ORIGINALLY PUBLISHED IN <EM>JOURNAL OF CELL BIOLOGY</EM>. Researchers in Singapore...
by UT Southwestern Medical Center Immunofluorescent staining of Npc1-deficient mouse cerebellum, with Purkinje neurons in red, activated microglia in green, and nucleus in blue. Massive microglia infiltration and loss of Purkinje neurons cause severe neurological disease in Niemann-Pick disease type C. Credit: Ting-Ting Chu UT Southwestern researchers have identified an immune protein tied to the rare neurodegenerative condition...
by Erik de Wit, University of Queensland (A) Representative fluorescent image of the PINK-1::GFP translational reporter in a myo-3p::mCherry background. The white box is magnified in the panel below, and body wall muscle cells are indicated by yellow dashed lines. Scale bar, 10 μm. (B) Quantification of mitophagy in body wall muscle cells. Columns are means...
ELIFE Weakened electrical signals in the brain may be an early warning sign of age-related neurodegenerative diseases such as Alzheimer’s disease, suggests a study published today in eLife. The findings hint at new ways to identify early on patients who may have an age-related brain disease. They also provide new insights into the changes that occur...
ELIFE Scientists have revealed a potential mechanism for how traumatic brain injury leads to neurodegenerative diseases, according to a study in fruit flies, and rat and human brain tissue, published today in eLife. The results could aid the development of treatments that halt the progression of cell damage after brain injury, which can otherwise lead to...
