Nagoya, Japan – Neurodegenerative diseases are incurable and debilitating conditions that result in progressive degeneration and death of nerve cells, which leads to problems with movement or mental functioning. Examples include Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ALS is characterized by degeneration of motor neurons, while FTD is characterized by progressive...
Tag: <span>neurodegenerative diseases</span>
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Does stem cell therapy offer the best hope for neurodegenerative diseases?
Rejuvenation Research is the premier peer-reviewed journal providing cutting-edge research on rejuvenation therapies in the laboratory and clinic. As the brain has limited capability for self-repair or regeneration, stem cells may represent the best therapeutic approach for counteracting damage to or degeneration of brain tissue caused by injury, aging, or disease. Although preclinical testing of...
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Viral vectors for gene transfer travel longer distances in the brain than thought
Gene transfer as a treatment of neurodegenerative diseases Where viral vectors ‘travel’ and which types of neural cells they infect, can be visualized by fluorescent Proteins being transmitted. Gene transfer is seen as a hopeful therapy for Alzheimer’s and Parkinson’s patients. The approach involves using harmless laboratory-produced viruses to introduce important genes into the brain...
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Tau prevents synaptic transmission at early stage of neurodegeneration
Tau proteins are involved in more than twenty neurodegenerative diseases, including various forms of dementia. These proteins clump together in patients’ brains to form neuronal tangles: protein aggregation that eventually coincides with the death of brain cells. Prof. Patrik Verstreken’s research team (VIB-KU Leuven) has now discovered how tau disrupts the functioning of nerve cells,...
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Researchers identify link between birth defect and neurodegenerative diseases
A new study has found a link between neurological birth defects in infants commonly found in pregnant women with diabetes and several neurodegenerative diseases, including Alzheimer’s, Parkinson’s and Huntington’s diseases. This is the first time this link has been identified; it may indicate a new way to understand, and perhaps treat, both neural tube...
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Discovery of novel autophagy regulators for treatment of neurodegenerative diseases
Synthesised curcumin analog C1 specifically binds to TFEB and promotes its nuclear translocation, and then activates autophagy and lysosome biogenesis to degrade alpha-synuclein. A research team led by Professor Li Min, Director of the Teaching and Research Division (CMTR), and Director of the Mr and Mrs Ko Chi Ming Centre for Parkinson’s Disease Research...
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Cell disposal faults could contribute to Parkinson’s, study finds
A fault with the natural waste disposal system that helps to keep our brain cell ‘batteries’ healthy may contribute to neurodegenerative disease, a new study has found. The research, led by academics at The University of Nottingham and published in the journal Cell Death and Disease, centres on problems with mitochondria — the powerhouses which produce...