Publication in Nature Communications HEINRICH-HEINE UNIVERSITY DUESSELDORF Proteins are central components of living material. These complex molecules made up of combinations of individual amino acids in some cases comprise thousands of individual atoms and have sophisticated three dimensional shapes. The term ‘fold’ is used to describe this structure. The fold of a protein determines its biological function. ...
Tag: <span>Neurodegenerative</span>
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The activity of disease allele-selective zinc finger proteins in preclinical models of Huntington’s disease
by Sangamo Therapeutics, Inc. Sangamo Therapeutics, Inc., a genomic medicine company, today announced the publication of a manuscript describing the activity of allele-selective zinc finger protein transcription-factors (ZFP-TFs) in preclinical models of Huntington’s disease (HD). The data were published online on July 1 and will appear in the July 2019 issue of Nature Medicine. The...
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Studies identify mechanism key to removal of protein aggregates from cells
Mass. General team’s findings may have application to treatment of cancer, neurodegenerative disorders MASSACHUSETTS GENERAL HOSPITAL Massachusetts General Hospital (MGH) investigators have discovered the mechanism by which cells sense dysfunction of the proteasome – a cellular component that degrades unneeded or defective proteins – and respond in a previously undescribed manner, by editing the amino acid sequence of a key sensing protein....
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Virtual reality could be used to recalibrate the perception of time
Posted Today Virtual Reality (VR) has a million different uses. For some it is a perfect gaming media and for others – simulation tool or even a system helping perfecting car assembly process. Now scientists from the University of Waterloo say that VR could help treating people with neurological disorders such as autism, schizophrenia and Parkinson’s disease. Time perception is very...
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Alzheimer’s: 9 new genetic risk factors found
New research, published in the journal Nature Genetics, identifies new genetic risk factors for Alzheimer’s disease. It also uncovers novel biological mechanisms that may lead to this neurodegenerative condition. About 5.7 million people in the United States are currently living with Alzheimer’s disease. A recent report issued by the Centers for Disease Control and Prevention (CDC) predicts that by the year 2060, this number...
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Study opens new therapeutic avenue for mitochondria malfunction
Jefferson scientists identify key interaction controlling calcium’s access to the cell’s powerhouse THOMAS JEFFERSON UNIVERSITY (PHILADELPHIA)–A surprising offender has been emerging to drive the progression of Parkinson’s, Alzheimer’s, Huntington’s and other neurodegenerative diseases: calcium. Calcium controls the production of fuel in mitochondria, the cell’s powerhouses. But too much calcium can lead to cellular damage and even...
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Researchers identify new potential biotherapy for Alzheimer’s disease
Researchers at the University of Florida have discovered that a modified version of an important immune cell protein could be used to treat Alzheimer’s disease. The study, which will be published August 29 in the Journal of Experimental Medicine, reveals that soluble versions of a protein called TLR5 can reduce the buildup of amyloid plaques in the...
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Researchers work on scientific foundation for new forms of therapy in neurodegenerative processes
Protective proteins that mitigate the destruction of nerve cells after a stroke can be administered into the brain through the nose, as Heidelberg University researchers demonstrated using a mouse model. The team led by Prof. Dr. Hilmar Bading at the Interdisciplinary Center for Neurosciences (IZN) is laying the scientific groundwork for new forms of therapy...
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Discovery presents treatment hope for Alzheimer’s and other neurodegenerative diseases
UNIVERSITY OF SOUTH AUSTRALIA There is new hope for the treatment of Alzheimer’s and other neurological diseases following a ground-breaking discovery made by an Australian-Chinese research collaboration. IMAGE: THIS IS A 3D ILLUSTRATION OF NERVE CELLS, CONCEPT FOR NEUROLOGICAL DISEASES, TUMORS AND BRAIN SURGERY. Researchers from the University of South Australia and the Third Military Medical University...
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Metabolomics applications for precision nutrition, formula, and Neurodegenerative disorders
Metabolomics is the latest omics systems science technology with emerging applications towards psychiatry, personalized medicine, and most recently, precision nutrition research. Infant formula, for example, is manufactured to match the molecular composition of human milk. A new study reporting on the comparative lipid profiles of infant formulas and human milk using metabolomics is published in OMICS: A...