by Tokyo University of Agriculture and Technology Credit: Engin Akyurt from PexelsPremenstrual syndrome (PMS) is a relatively common condition that affects most women who menstruate, at some point in their lives. Typically, PMS can cause a variety of symptoms, including mood swings, irritability, bloating, and fatigue. Moreover, PMS tends to worsen the symptoms of certain psychiatric...
Tag: <span>Neurodevelopmental disorders</span>
Post
Map of disease-causing mutations in neurodevelopmental disorders and cancer revealed
by Wellcome Trust Sanger Institute Experimental design overview. a Two independent sgRNAs and associated HDR variant libraries are designed at the 5′ and 3′ end of each exon. b The sgRNA, together with the HDR template library are transfected into LIG4-KO Cas9-expressing HAP1 cells. HDR utilizes the library as a template for repair of the sgRNA-directed...
Post
Increased risk of testicular cancer in people with neurodevelopmental disorders
by Uppsala University Testicular germ cell tumor-specific mortality in patients with and without prior psychiatric disorders. Cumulative incidence function using non-testicular cancer mortality as competing event for cause-specific testicular cancer mortality in patients with (a) non-seminoma and (b) seminoma with and without history of psychiatric diagnosis. Credit: British Journal of Cancer (2023). DOI: 10.1038/s41416-023-02260-8 A new study by researchers at...
Post
Disrupted flow of brain fluid may underlie neurodevelopmental disorders
by Washington University School of Medicine The addition of a magenta tracer molecule illustrates the flow of fluid around the brain, revealing that neurons in the hippocampus (cyan), the brain’s memory center, are awash in fluid. Researchers at Washington University School of Medicine in St. Louis have discovered that this fluid flows to areas critical for normal...
Post
Brain enzyme found to activate dormant neural stem cells, providing insight into neurodevelopmental disorders
by Duke-NUS Medical School When quiescent neural stem cells in the fruit fly larval brain are activated, they can generate new neurons. In the image, the nucleus of quiescent neural stem cells is labelled by a marker of neural stem cells named Deadpan in magenta, and the cell outline is marked in green. Credit: Wang Hongyan...
Post
Inflammation and autism—an important piece of the puzzle
by Delthia Ricks , Medical Xpress Autism spectrum disorder has neither a distinct pathogenesis nor pharmaceutical treatment, yet evidence continues to mount demonstrating immune dysfunction and inflammation in specific brain regions of children diagnosed with the neurodevelopmental condition. A collaborative group of researchers in Boston and Italy has discovered that pro- and anti-inflammatory cytokines apparently...
Post
New method helping to find deletions and duplications in the human genome
by Sam Sholtis, Pennsylvania State University A new machine-learning method accurately identifies regions of the human genome that have been duplicated or deleted—known as copy number variants—that are often associated with autism and other neurodevelopmental disorders. The new method, developed by researchers at Penn State, integrates data from several algorithms that attempt to identify copy number variants from exome-sequencing data—high-throughput DNA sequencing of only the...
Post
Neurodevelopmental Disorders Involving Epilepsy Include Some Distinct De Novo Variants
Jun 25, 2018, | staff reporter NEW YORK (GenomeWeb) – Members of an international team led by investigators at the University of Leipzig Hospitals and Clinics have started characterizing the distinct de novo variants (DNVs) involved in neurodevelopmental disorders (NDDs) that cause epilepsy symptoms. Using the DNV profiles of the members of 6,753 parent-child trios affected by diverse NDDs,...
Post
Improvement of the genetic decoding of neurodevelopmental disorders
A result that will help in the future diagnosis of children with neurodevelopmental disorders, such as intellectual disability, autism or schizophrenia. A video illustrates this scientific analysis with medical applications. A key question in biology is understanding how brain works. Neurons transmit information in the form of electrical impulses and chemical signals. Alterations in the...