by Cell Press Thisis a high-resolution image of the large number of new neurons being produced (in red) in the hippocampus of middle-aged mice, treated with the drug that ablates senescent neural stem cells in the stem cell niche. Credit: Michael Fatt Destroying senescent cells in the aging stem cell niche enhances hippocampal neurogenesis and...
by University of Bern Using a technique called optogenetics, the activity of cells in the brain can be specifically suppressed with light pulses. Credit: Pascal Gugler / Insel Gruppe Despite our broad understanding of the different brain regions activated during rapid-eye-movement sleep, little is known about what this activity serves for. Researchers at the University...
by University of California, San Francisco A little-studied liver protein may be responsible for the well-known benefits of exercise on the aging brain, according to a new study in mice by scientists in the UC San Francisco Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research. The findings could lead to new...
by University of Southern California New USC research reveals how APOE4, a genetic culprit for Alzheimer’s disease, triggers leaks in the brain’s plumbing system, allowing toxic substances to seep into the brain areas responsible for memory encoding and other cognitive functions. The damage is linked to future problems in learning and memory, even when the...
by Helmholtz Association of German Research Centres In mammalian adult brains, neural stem cells are only present in few specific regions, so-called niches. Only these niches are capable of generating new neurons. For the first time, researchers have defined the proteome of these niches, the entire set of expressed proteins, and compared it to other...
Scientists once thought that mammals entered adulthood with all of the neurons they would ever have, but studies from the 60s found that new neurons are generated in certain parts of the adult brain and pioneering studies from the 90s helped identify their origins and function. In the latest update, a team of researchers has...
