MIT researchers find that in mice and human cell cultures, lipid nanoparticles can deliver a potential therapy for inflammation in the brain, a prominent symptom in Alzheimer’s.Some Covid-19 vaccines safely and effectively used lipid nanoparticles (LNPs) to deliver messenger RNA to cells. A new MIT study shows that different nanoparticles could be used for a...
Tag: <span>neuroinflammation</span>
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Nanoparticle-delivered RNA reduces neuroinflammation in lab tests
Some Covid-19 vaccines safely and effectively used lipid nanoparticles (LNPs) to deliver messenger RNA to cells. A new MIT study shows that different nanoparticles could be used for a potential Alzheimer’s disease (AD) therapy. In tests in multiple mouse models and with cultured human cells, a newly tailored LNP formulation effectively delivered small interfering RNA...
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Nanoparticle-delivered RNA reduces neuroinflammation in lab tests
In mice and human cell cultures, MIT researchers showed that novel nanoparticles can deliver a potential therapy for inflammation in the brain, a prominent symptom in Alzheimer’s disease Peer-Reviewed Publication PICOWER INSTITUTE AT MIT A FIGURE FROM THE PAPER SHOWS THAT AN SIRNA DELIVERED BY A LIPID NANOPARTICLE WAS ABLE TO REDUCE EXPRESSION OF THE...
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Brain clues in the battle against long COVID: study pinpoints neuroinflammation
Dr. Priyom Bose, Ph.D.By Dr. Priyom Bose, Ph.D.Oct 25 2023Reviewed by Lily Ramsey, LLMThe coronavirus disease 2019 (COVID-19) pandemic has led to a public health crisis known as long-COVID, or post-acute sequelae of COVID-19 (PASC). A recent study published on the bioRxiv* preprint server analyzed the relationship between circulating markers of vascular dysfunction and neuroinflammation...
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Mechanism facilitates brain metastasis from breast cancer and melanoma by inducing neuroinflammation
by Tel-Aviv University Brain metastatic burden and survival in mice injected with breast cancer cells. a. Experimental scheme analyzed in (b,c). b. Survival curve analysis of WT and Lcn2-/- mice injected intracardially with BT-EO771 cells, (WT n = 10, Lcn2-/- n = 9 mice) (Kaplan–Meier curve, log-rank test). c. Quantification of brain metastatic burden for mice in (a), quantified as %...
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Repurposing cancer drug to treat neuroinflammation
by Karolinska Institutet Graphical abstract. Credit: EMBO reports (2022). DOI: 10.15252/embr.202154499 The repurposing of FDA-approved drugs for alternative diseases is a faster way of bringing new treatments into the clinic. Researchers at Karolinska Institutet in Sweden have repurposed a cancer drug for treatment of neuroinflammatory diseases such as multiple sclerosis. A novel drug carrier was also developed...
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Novel small molecule potently attenuates neuroinflammation in brain and glial cells
UNIVERSITY OF ALABAMA AT BIRMINGHAM IMAGE: PETER KING CREDIT: UAB BIRMINGHAM, Ala. – Neuroinflammation can worsen outcomes in stroke, traumatic brain injury or spinal cord injury, as well as accelerate neurodegenerative diseases like ALS, Parkinson’s or Alzheimer’s. This suggests that limiting neuroinflammation may represent a promising new approach to treat neurological diseases and neuropathic pain that...
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LSL60101 compound reduces neuroinflammation and improves cognition
The LSL60101 compound, a specific ligand of the I2-IR receptors in the brain, could shed light on the development of future strategies against Alzheimer’s disease. This is stated in the recent studies by the Research Group on Medicinal Chemistry and Pharmacology of Neurodegenerative Diseases of the University of Barcelona, published in the journals European Journal of Medicinal Chemistry and British...
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Lack of key neuropeptide induces neuroinflammation to impair neural stem cells and limit new neuron production
by Mark Derewicz, University of North Carolina at Chapel Hill School of Medicine The dentate gyrus houses neural stem cells in a thin zone near the blue-labeled granule cells. Cholecystokinin interneurons (red) extend elaborate processes and release neuropeptide onto astrocytes (green) to induce neurogenesis in brain of adult mouse. Credit: University of North Carolina at Chapel...
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Immune Cells in Spinal Fluid of Multiple Sclerosis Patients Identified as Likely Disease Drivers
Results Lay Groundwork for New, More Targeted Immune Therapies. New UC San Francisco research sheds light on how immune system B cells that infiltrate the central nervous system may drive multiple sclerosis (MS), pointing the way to a new generation of targeted immune therapies to halt the progression of the disease. MS is a common...
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