By Syed S. A.Reviewed by Danielle Ellis, B.Sc. What is neuroinflammation?Causes of neuroinflammationThe impact of neuroinflammationPotential treatments and preventionReferences What is neuroinflammation? Neuroinflammation refers to an inflammatory reaction in the brain or spinal cord. It is driven by the production of molecules such as cytokines, chemokines, reactive oxygen species (ROS), and secondary messengers, which are released by...
Tag: <span>neuroinflammation</span>
Post
New research identifies potential therapeutic target for amyotrophic lateral sclerosis
September 10, 2024 by VIB (the Flanders Institute for Biotechnology) Credit: Cell Reports (2024). DOI: 10.1016/j.celrep.2024.114719Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is the most common degenerative motor neuron disease in adults. It is characterized by a selective loss of motor neurons, resulting in progressive muscle weakness and paralysis, as well as...
Post
Nanoparticle-Delivered RNA Reduces Neuroinflammation in Lab Tests
MIT researchers find that in mice and human cell cultures, lipid nanoparticles can deliver a potential therapy for inflammation in the brain, a prominent symptom in Alzheimer’s.Some Covid-19 vaccines safely and effectively used lipid nanoparticles (LNPs) to deliver messenger RNA to cells. A new MIT study shows that different nanoparticles could be used for a...
Post
Nanoparticle-delivered RNA reduces neuroinflammation in lab tests
Some Covid-19 vaccines safely and effectively used lipid nanoparticles (LNPs) to deliver messenger RNA to cells. A new MIT study shows that different nanoparticles could be used for a potential Alzheimer’s disease (AD) therapy. In tests in multiple mouse models and with cultured human cells, a newly tailored LNP formulation effectively delivered small interfering RNA...
Post
Nanoparticle-delivered RNA reduces neuroinflammation in lab tests
In mice and human cell cultures, MIT researchers showed that novel nanoparticles can deliver a potential therapy for inflammation in the brain, a prominent symptom in Alzheimer’s disease Peer-Reviewed Publication PICOWER INSTITUTE AT MIT A FIGURE FROM THE PAPER SHOWS THAT AN SIRNA DELIVERED BY A LIPID NANOPARTICLE WAS ABLE TO REDUCE EXPRESSION OF THE...
Post
Brain clues in the battle against long COVID: study pinpoints neuroinflammation
Dr. Priyom Bose, Ph.D.By Dr. Priyom Bose, Ph.D.Oct 25 2023Reviewed by Lily Ramsey, LLMThe coronavirus disease 2019 (COVID-19) pandemic has led to a public health crisis known as long-COVID, or post-acute sequelae of COVID-19 (PASC). A recent study published on the bioRxiv* preprint server analyzed the relationship between circulating markers of vascular dysfunction and neuroinflammation...
Post
Mechanism facilitates brain metastasis from breast cancer and melanoma by inducing neuroinflammation
by Tel-Aviv University Brain metastatic burden and survival in mice injected with breast cancer cells. a. Experimental scheme analyzed in (b,c). b. Survival curve analysis of WT and Lcn2-/- mice injected intracardially with BT-EO771 cells, (WT n = 10, Lcn2-/- n = 9 mice) (Kaplan–Meier curve, log-rank test). c. Quantification of brain metastatic burden for mice in (a), quantified as %...
Post
Repurposing cancer drug to treat neuroinflammation
by Karolinska Institutet Graphical abstract. Credit: EMBO reports (2022). DOI: 10.15252/embr.202154499 The repurposing of FDA-approved drugs for alternative diseases is a faster way of bringing new treatments into the clinic. Researchers at Karolinska Institutet in Sweden have repurposed a cancer drug for treatment of neuroinflammatory diseases such as multiple sclerosis. A novel drug carrier was also developed...
Post
Novel small molecule potently attenuates neuroinflammation in brain and glial cells
UNIVERSITY OF ALABAMA AT BIRMINGHAM IMAGE: PETER KING CREDIT: UAB BIRMINGHAM, Ala. – Neuroinflammation can worsen outcomes in stroke, traumatic brain injury or spinal cord injury, as well as accelerate neurodegenerative diseases like ALS, Parkinson’s or Alzheimer’s. This suggests that limiting neuroinflammation may represent a promising new approach to treat neurological diseases and neuropathic pain that...
Post
LSL60101 compound reduces neuroinflammation and improves cognition
The LSL60101 compound, a specific ligand of the I2-IR receptors in the brain, could shed light on the development of future strategies against Alzheimer’s disease. This is stated in the recent studies by the Research Group on Medicinal Chemistry and Pharmacology of Neurodegenerative Diseases of the University of Barcelona, published in the journals European Journal of Medicinal Chemistry and British...
- 1
- 2