HEALTH 15 May 2024ByDAVID NIELD Brain tissue scan, with the bright red ring showing a protein clump that only shows up in patients with SCA4. (Mandi Gandelman) You might not have heard of spinocerebellar ataxia type 4 (SCA4), as it’s an incredibly rare condition – but after a quarter of a century of looking, the...
by National Institutes of Health Localization of α-syn Ser129P and effects of phosphorylation on synaptic targeting. Credit: Neuron (2023). DOI: 10.1016/j.neuron.2023.11.020Researchers have discovered that a protein called phosphorylated α-synuclein, which is associated with several neurodegenerative diseases such as Parkinson’s disease and Lewy body dementia, is also involved in the normal processes of how neurons communicate with...
by Anna Rogers, NIH/National Human Genome Research Institute Bi-allelic variants in ATG4D segregate with a neurodevelopmental disorder in three individuals from two unrelated families. a Neuroimaging of Individual 1 showing mild cerebellar atrophy disproportionately involving the superior cerebellar hemispheres and vermis at 5 years 3 months (arrowhead in T2-weighted sagittal view image, left panel). There...
by The Mount Sinai Hospital Researchers at the Icahn School of Medicine at Mount Sinai and NCATS identified compounds that reversed the effects of several neurodegenerative diseases called lysosomal storage disorders (LSDs) in patient cells and mice. LSDs are characterized by genetic defects that prevent the cell’s lysosomes from breaking down and recycling fats, sugars...
by Paul Tumarkin, University of Arizona Robin Polt (right) coaches undergraduate student Hannah Kuo Feinberg as she works on a glycopeptide project in Polt’s lab. Credit: Paul Tumarkin/Tech Launch Arizona University of Arizona researchers have developed a new class of drugs that is able to cross the blood-brain barrier and could be used to treat...
UNIVERSITY OF CALIFORNIA – SAN DIEGO IMAGE: A SMARTPHONE USER CAN IMAGE THE EYE USING THE RGB SELFIE CAMERA AND THE FRONT-FACING NEAR-INFRARED CAMERA INCLUDED FOR FACIAL RECOGNITION. MEASUREMENTS FROM THIS IMAGING COULD BE USED TO ASSESS THE USER’S COGNITIVE CONDITION. CREDIT: DIGITAL HEALTH LAB Researchers at the University of California San Diego have developed...
by Jim Hannah, Wright State University Effect of altering glucose on AIS length in mouse cortical cultures. A, Example images of the AIS after 24 h of exposure to normal culture media containing 25 mm glucose, high-glucose media containing 50 mm glucose, or normal media containing 25 mm glucose with 25 mm mannitol added as an...
by Ecole Polytechnique Federale de Lausanne Enrico Amico, a scientist and SNSF Ambizione Fellow at EPFL’s Center for Neuroprosthetics and EPFL’s Medical Image Processing Lab. Credit: Alain Herzog / EPFL An EPFL scientist has found that brain fingerprints—or maps of the neural connections within our brain—can be used to detect a decline in cognitive ability. That’s...
by Ingrid Fadelli, Medical Xpress Credit: Boulting et al. The expression of genes in response to neuronal activity can significantly influence the human brain’s development over time. While many neuroscientists have investigated the epigenetic effects of neuronal activity, most of their studies were conducted on mice, thus the understanding of these processes in humans is...
by Cincinnati Children’s Hospital Medical Center Without even knowing it, most of us carry around latent Herpes Simplex Virus (HSV) in our nervous system—a simple result of being born and living together with others carrying the virus. This illustration shows the stepwise apoptotic (a form of cell death) path that a trigeminal sensory neuron undergoes...
