by Claire Kowalick, University of Texas Health Science Center at San Antonio Credit: Biochemistry (2023). DOI: 10.1021/acs.biochem.3c00371 Messenger ribonucleic acid (mRNA)-based therapeutics and the potential of mRNA as a treatment for various conditions has been researched for decades. A key challenge remains finding a delivery system that enables enough of the mRNA to reach target tissues safely...
Tag: <span>neurological treatments</span>
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The brain’s protein-destruction machine learns new tricks at synapses, potential target for neurological treatments
by Aarhus University Credit: Pixabay/CC0 Public Domain Scientists have long known that the cells’ “protein destruction machine,” the proteasome, plays a crucial role in protein clearance within the brain. However, a new study published in Science has revealed that its essential component, the 19S regulatory particle, has an independent “moonlighting” role at synapses, and thus might offer new...