A trial HIV vaccine has triggered broadly neutralizing antibodies in humans after just two immunizations.News Published: May 20, 2024 | Blake Forman Read time: 3 minutes Infection with HIV is currently manageable with lifelong antiretroviral medications, but neither a vaccine nor a cure is available. A critical roadblock in preventative vaccine development has been the...
Tag: <span>neutralizing antibodies</span>
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New omicron subvariant largely evades neutralizing antibodies
by Karolinska Institutet BA.2.75.2 escapes neutralizing antibodies. (A) Differences from BA.2 in BA.2.75 (orange), and BA.2.75.2 (red, underlined), depicted upon the SARS-CoV-2 BA.2 receptor binding domain (pdb:7UB0). Sensitivity of SARS-CoV-2 omicron sublineages and ancestral B.1 (D614G) to neutralization by monoclonal antibodies (B), and randomly sampled sera from blood donated in Stockholm, Sweden, between Nov 8–14,...
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A page from the COVID therapy playbook: Unleashing a flood of neutralizing antibodies against HIV
by Delthia Ricks , Medical Xpress A combination of the broadly neutralizing antibodies (bNAbs) and antibodies against the integrin reduced B cell follicles aggregates (brown spots) more than the bNAbs alone. Credit: I Frank et al., Science Translational Medicine (2021) For more than 40 years a goal that too often has proved elusive is a pharmaceutical defeat...
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Neutralizing antibodies persist against SARS-CoV-2 at least a year after infection
By Sally Robertson, B.Sc. Jul 19, 2021 Researchers in Finland have conducted a study showing that the neutralizing antibodies generated following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – generally persist for at least a year. “Studies of individuals who have recovered from natural...
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Details about broadly neutralizing antibodies provide insights for universal flu vaccine
by University of Chicago Medical Center This digitally-colorized transmission electron microscopic image depicts the ultrastructural details of an influenza virus particle. New research from an immunology team at the University of Chicago may shed light on the challenges of developing a universal flu vaccine that would provide long-lasting and broad protection against influenza viruses. The study, published October...