by Ludwig Institute for Cancer Research Graphical abstract. Credit: Daniel Hirschhorn et al, T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants, Cell (2023). DOI: 10.1016/j.cell.2023.03.007 Two independent Ludwig Cancer Research studies published in the current issue of the journal Cell show that immune cells known as neutrophils, whose abundance in the microenvironment of tumors has traditionally...
Tag: <span>Neutrophils</span>
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Researchers identify neutrophils as major culprits in treatment resistance of pancreatic cancer
by Sylvester Comprehensive Cancer Center Credit: Unsplash/CC0 Public Domain Researchers have shown for the first time exactly how immature neutrophils—white blood cells that are an important part of the immune system—are hijacked by pancreatic cancers to drive immunosuppression and treatment resistance. The study, led by investigators at Sylvester Comprehensive Cancer Center at the University of Miami...
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Could neutrophils be the secret to cancer’s Achilles’ heel?
by University of Chicago Medical Center Credit: CC0 Public Domain A study published in the June 10, 2021 issue of Cell describes a remarkable new mechanism by which the body’s own immune system can eliminate cancer cells without damaging host cells. The findings have the potential to develop first-in-class medicines that are designed to be selective for cancer...
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The unexpected repair function of neutrophils
by Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.) From left to right: Andrés Hidalgo, Iván Ballesteros, and Andrea Rubio. Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) have discovered that neutrophils, the most abundant cells of the innate immune system, have many more functions in the body than previously thought. This finding suggests...
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Gut microbiome translates stress into sickle cell crises
ALBERT EINSTEIN COLLEGE OF MEDICINE July 30, 2020–(BRONX, NY)–A new study shows how chronic psychological stress leads to painful vessel-clogging episodes–the most common complication of sickle-cell disease (SCD) and a frequent cause of hospitalizations. The findings, made in mice, show that the gut microbiome plays a key role in triggering those episodes and reveals possible...
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COULD TINY ‘DISTRACTING’ RODS SAVE COVID-19 PATIENTS?
White blood cells called neutrophils may be central to the immune system overreaction that can kill COVID-19 patients. New research finds that rod-shaped particles can take them out of circulation. The top cause of death for COVID-19 patients echoes the way the 1918 influenza pandemic killed: their lungs fill with fluid and they essentially drown....
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Stimulating immune cleanup crew offers a possibility for treating rare disorder
by Katherine Unger Baillie, University of Pennsylvania By mimicking the cellular cleanup process known as efferocytosis, researchers from the School of Dental Medicine have identified a new strategy for addressing a rare genetic disease that causes inflammation around the body. Credit: George Hajishengallis Owing to a rare genetic mutation, individuals with leukocyte adhesion deficiency type...
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Salmonella loves hydrogen peroxide – and helps your body make more of it
Salmonella is a nasty little bacterium. The Centers for Disease Control and Prevention estimates that it sickens one in six Americans each year, with illnesses ranging from mild to fatal. Part of the reason that Salmonella is so effective in making us sick is that it is able to turn the body‘s defense mechanism to its advantage. Now, new...
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Researchers find elusive source of most abundant immune cell
Neutrophils—short-lived, highly mobile and versatile—outnumber all other immune cells circulating through the bloodstream. Yet, despite the cells’ abundance, the progenitor cell that only gives rise to neutrophils had eluded all efforts to track it down. Now, researchers at La Jolla Institute for Allergy and Immunology identified a progenitor of neutrophils in the bone marrow of...