by Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.) Graphical summary. Credit: Nature Cardiovascular Research (2024). DOI: 10.1038/s44161-023-00412-wA research team based at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) in Madrid and Aarhus University in Denmark has identified an important mechanism that can result in the regression, or shrinkage, of atherosclerotic plaques. The study identifies...
by Virginia Commonwealth University Axial CT image with i.v. contrast. Macrocystic adenocarcinoma of the pancreatic head. Credit: public domain Preclinical research published in the Journal for ImmunoTherapy of Cancer points to a promising new treatment option for people with pancreatic cancer. Researchers from VCU Massey Comprehensive Cancer Center and the VCU Institute of Molecular Medicine (VIMM)...
by Wiley Credit: WileyImmunotherapies for cancer aim to induce the immune system to combat cancer cells more effectively. In the journal Angewandte Chemie International Edition, a Chinese research team has now described a new, modular strategy for T-cell-based immunotherapy that manages to work without complex genetic modifications. Modulation of cell–cell communications through an ingenious regulatory...
by Ben-Gurion University of the Negev VDAC1 is highly expressed in the neuropil surrounding the Aβ plaques of the 5 × FAD mouse model. a–d Representative cortical and hippocampal sections from WT and 5 × FAD mice treated and untreated with VBIT-4, IHC stained for Aβ (a, b) or VDAC1 (c, d). Higher magnifications of selected areas are shown...
by Vanderbilt University Medical Center Jeffrey Rathmell, PhD, (left), and Kelsey Voss, PhD, led a multidisciplinary team that identified iron metabolism in T cells as a potential target for treating lupus. Credit: Vanderbilt University Medical Center Targeting iron metabolism in immune system cells may offer a new approach for treating systemic lupus erythematosus (SLE)—the most...
DZNE – GERMAN CENTER FOR NEURODEGENERATIVE DISEASES A drug that is used to treat immune diseases could help patients with incurable amyotrophic lateral sclerosis (ALS) in the future: Initial indications suggest that the immune system plays a role in the usually very rapid progression of ALS. In a clinical trial at the DZNE’s Bonn and...
by University of Calgary Vascularized wound under the microscope. Credit: Rachel Kratofil University of Calgary researchers have identified a promising new approach to treating bacterial skin infections. In a study recently published in Nature, first author Dr. Rachel Kratofil, Ph.D., and co-senior authors Drs. Paul Kubes, Ph.D., Justin Deniset, Ph.D., and their research team show new...
by University of Bonn ASC specks shown here in different colors are large complexes of many copies of the ASC protein. They can cause immense damage in the tissue. Credit: Franklin Lab / University of Bonn The cells in our body have a sophisticated alarm system, the inflammasome. Its central component is the so-called ASC...
SCRIPPS RESEARCH INSTITUTE IMAGE: A SCRIPPS RESEARCH TEAM FOUND A COMPOUND THAT PROTECTS AGAINST DIABETES-LIKE METABOLIC CHANGES IN OBESE MICE, INCLUDING THE REDUCTION IN LIVER FAT DEPOSITS OF TREATED OBESE MICE (RIGHT) COMPARED TO UNTREATED (LEFT). CREDIT: SCRIPPS RESEARCH LA JOLLA, CA—A team of scientists from Scripps Research has conducted promising early tests of a...
by University of Illinois at Urbana-Champaign Researchers discovered a small molecule, ErSO, that eradicates breast cancers in mice by targeting a pathway that protects cancer cells. Credit: L. Brian Stauffer A new approach to treating breast cancer kills 95-100% of cancer cells in mouse models of human estrogen-receptor-positive breast cancers and their metastases in bone, brain, liver,...
