by Laurie Fickman, University of Houston Credit: Kindel Media from PexelsNew biomarkers with improved diagnostic performance for early detection of lupus nephritis have been discovered in the University of Houston lab of Chandra Mohan, a pioneer in lupus research. Early identification of renal involvement in lupus and prompt treatment are essential in reducing the pain, suffering...
KOREA UNIVERSITY COLLEGE OF MEDICINE IMAGE: LOCAL GYRIFICATION INDEX MAY BE A RELATIVELY STABLE NEUROIMAGING MARKER FOR ESTABLISHING THE PREDISPOSITION TO MAJOR DEPRESSIVE DISORDER CREDIT: KYU-MAN HAN AND BYUNG-JOO HAM In appearance, the human brain’s outermost layer, called the cortex, is a maze of tissue folds. The peaks or raised surfaces of these folds, called...
by El Gibson, University of New Mexico Health Sciences Center Functional pathway analyses of VEC in AD using STRING. Our functional pathway analyses suggest significant interactions of CDH5 with APOE and the NRP1-PLXNA4-SEMA3A complex. The evidence score for CDH5–APOE interaction is 0.41 and that for the CDH5–NRP-1 interaction is 0.51. Data-mining results suggest that CDH5...
by Barbara Peters, Angelika Jacobs, University of Basel Credit: Wikimedia Commons The autoimmune disease multiple sclerosis can take a variety of courses. Determining the current and future course of the disease is important in order to slow down its course as much as possible. Researchers at the University of Basel have presented a biomarker whose values in...
MEDICAL UNIVERSITY OF VIENNA A MedUni Vienna research team has discovered a highly potent biomarker for clinical response to CAR-T cell therapy, describing the prerequisites for optimal use of this novel therapy for lymphoma treatment. The current findings are an essential step forward towards optimizing this promising therapy. The results of the study were recently published in the...
by American Chemical Society Graphical abstract. Credit: ACS Chemical Neuroscience (2022). DOI: 10.1021/acschemneuro.2c00342 A definitive diagnosis of Alzheimer’s disease (AD) was once only possible after someone had died, but recent biomarker studies have led to the development of imaging and spinal fluid tests for those still living. However, the tests can only monitor severe disease, differentiating advanced...
LAWSON HEALTH RESEARCH INSTITUTE LONDON, ON- A new diagnostic method could help identify one of the deadliest types of interstitial lung disease (ILD) sooner, allowing for faster treatment and improved patient outcomes. Idiopathic pulmonary fibrosis (IPF) is one of the most serious and common types of ILD, occurring most often in patients 60 and older...
NAGOYA CITY UNIVERSITY IMAGE: BBB KW MAP (A), QSM (B), AND [11C]PIB-PET SUVR (C) FROM AN APOE Ɛ4 NONCARRIER (Ε3/Ε3), A HETEROZYGOTE (Ε3/Ε4), AND A HOMOZYGOTE (Ε4/Ε4) ARE DISPLAYED. CREDIT: NAGOYA CITY UNVIERSITY Alzheimer’s disease (AD) is the most common type of dementia. An etiology of AD would be excessive accumulation of toxic forms of...
by Laurie Fickman, University of Houston Credit: CC0 Public Domain After examining 398 proteins, a University of Houston College of Pharmacy researcher has found one that is an important biomarker predicting therapy outcome and a potential drug target in estrogen receptor-positive (ER+) breast cancer, which makes up approximately 80% of all breast cancers. The growth...
MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE IN THE HELMHOLTZ ASSOCIATION Multiple sclerosis, or MS for short, manifests itself slightly differently in each person – which is why some call it “the disease of a thousand faces.” Arguably the worst manifestation of MS is its chronic progressive form. Unlike the more common relapsing-remitting variant (RRMS), in...
