by Children’s Medical Research Institute (CMRI) Credit: Cell Chemical Biology (2023). DOI: 10.1016/j.chembiol.2023.11.008 A team from Children’s Medical Research Institute has discovered a new way to impair cancer cell growth, which could lead to the development of a new class of cancer therapeutics with minimal side-effects on normal cells. Professor Hilda Pickett, who leads CMRI’s...
by UC Davis Credit: CC0 Public Domain A non-hallucinogenic version of the psychedelic drug ibogaine, with potential for treating addiction, depression and other psychiatric disorders, has been developed by researchers at the University of California, Davis. A paper describing the work is published Dec. 9 in Nature. “Psychedelics are some of the most powerful drugs we...
By Michael Franco Currently in the animal-study stage, the hope is that the new compound could one day provide people with side-effect-free pain reliefCurrently in the animal-study stage, the hope is that the new compound could one day provide people with side-effect-free pain relief Depositphotos After screening 27 million compounds, researchers have found a small-molecule drug...
by University of Bonn The host RNA is methylated by MTr1 to a mature cap1 RNA. The influenza virus snatches the cap part of the mature host RNA to start viral replication. MTr1-deficient cells or cells treated with MTr1 inhibitors do not lead to IAV replication. Credit: Yuta Tsukamoto/UKB Viruses use the molecular repertoire of...
by University of Arizona The structure of compound 194 (yellow sticks) overlaid on an electrophysiology trace showing reduced sodium currents (yellow vs. black lines) from cells that are treated with compound 194. The structure illustrates the predicted interaction of CRMP2 (pink, PDB 2GSE) with the Nav1.7 channel (cyan, PDB 6J8G). Credit: University of Arizona Health...
by Northwestern University Credit: CC0 Public Domain Northwestern University scientists have identified the first compound that eliminates the ongoing degeneration of upper motor neurons that become diseased and are a key contributor to ALS (amyotrophic lateral sclerosis), a swift and fatal neurodegenerative disease that paralyzes its victims. In addition to ALS, upper motor neuron degeneration also results in...
