by Will Cushman, University of Wisconsin-Madison Characterization of the thrombosis-mediated navigation system. (A) Schematic of the thrombosis-mediated navigation system for P-aPD-1. Truncated tissue factor–Arg-Gly-Asp (RGD) (tTF-RGD), administered either by intravenous (i.v.) or p.t. routes, targets tumor neovasculature endothelial cells and initiates coagulation cascade to recruit anti–programmed cell death 1 (PD-1) antibody–conjugated platelets (P-aPD-1). P-aPD-1 is activated...