by University of Eastern Finland Quinazoline CA439 enhances the action of the antimicrobial peptide colistin through a triple mechanism of action that involves: 1, permeabilization of the bacterial outer membrane; 2, down-regulation of polymyxin resistance genes through the PhoP/PhoQ-PmrA/PmrB cascade; 3, alteration of electrochemical potential of the bacterial inner membrane. Credit: C. Asquith.A new collaborative study...
