by The Scripps Research Institute Chemoproteomic discovery of SLC15A4 inhibitors. Credit: Nature Chemical Biology (2024). DOI: 10.1038/s41589-023-01527-8Scientists from Scripps Research have developed a small molecule that blocks the activity of a protein linked to autoimmune diseases, including systemic lupus erythematosus (SLE) and Crohn’s disease. This protein, known as SLC15A4, has been considered largely “undruggable,” as most...
