by Anna Björklund, Identification of a conformational switch in c-MYC. a Overview of the MD strategy employed to identify regions that exhibit probe-induced conformational changes. b Normalized frequency distribution of Rg computed from the ensemble of structures generated from explicit solvent MD simulations in water (black) and water + benzene (red) for all nine c-MYC...
by Valerie Goodwin, University of Michigan Credit: Jacob Dwyer, Justine Ross / Michigan MedicineSystemic sclerosis causes the skin to tighten and harden resulting in a potentially fatal autoimmune condition that is associated with lung fibrosis and kidney disease. University of Michigan Health researchers have studied the pathology of systemic sclerosis to understand better the disease and...
by The Wistar Institute IFN signaling is activated in brain metastasis. a–c IFN signaling is activated in both human astrocytes and MDA231-BrM cells by coculture in vitro. N = 2 biologically independent experiments per condition. a Scheme of RNA sequencing experiment setup. b Ingenuity Pathway analysis (IPA) comparing BrM-induced changes in astrocytes and astrocyte-induced changes in BrM cells. c Heatmaps of genes in IFN signaling pathway from...
UNIVERSITY OF PENNSYLVANIA Atopic dermatitis, a common skin condition affecting both children and adults, is often thought of as an inflammatory disease that arises from a breakdown in the barrier function of the skin. Now a new study pinpoints a cascade of inflammatory signaling that precedes the appearance of skin ulcers, shedding light on the...
UNIVERSITY OF TAMPERE An international research team has discovered a principle that explains the metastasizing of prostate cancer. When cancer evolves within the prostate, multiple spatially intermixed cancer cell clones are created that may invade the organs surrounding the prostate. However, only one dominant cell clone spreads systemically in the body and creates metastases. In...
