by University of Barcelona Proposed mechanistic model for the hepatic effects of Gdf15 deficiency on fibrosis, gluconeogenesis and fatty liver via the TGF-β1-SMAD3 pathway. Credit: Metabolism (2024). DOI: 10.1016/j.metabol.2023.155772A study led by the University of Barcelona and the Biomedical Research Networking Center in Diabetes and Associated Metabolic Disorders (CIBERDEM) reveals how a new mechanism could improve...
Tag: <span>new mechanism</span>
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A new mechanism encouraging the brain to self-repair after an ischemic stroke
by Tokyo Medical and Dental University The neurons around an injured brain region will play major roles in promoting functional recovery through nervous system development, synapse organization, and remyelination; however, the molecular mechanisms triggering such a broad range of neural repair after brain injury remained unknown. Our study demonstrated that the secretion of PLA2G2E from perilesional...
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Unveiling a new mechanism that accelerates aging of adipose tissues
by Pohang University of Science and Technology Metabolic phenotype affected by aging and adipocyte-specific Crtc2 knockout. Adipocyte-specific Crtc2 knockout mice (Crtc2 AKO) confirmed a suppression of impaired glucose tolerance (A) and an increase in fat mass (B) caused by aging. Moreover, Crtc2 AKO mice exhibited a significant reduction in fat accumulation in the liver and adipose...
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Researchers discover a new mechanism of cancer immune defense
by Universitätsmedizin Magdeburg Graphical summary of inflammatory cell death induction of MHC-deficient and IFN-unresponsive tumors by CD4+ T cells in cooperation with iNOS-expressing myeloid cells. Credit: Nature (2023). DOI: 10.1038/s41586-023-06199-x An interdisciplinary team of researchers at the Otto-von-Guericke University in Magdeburg has gained new insights into how inflammatory mediators of pathogen defense can remotely drive cancer cells into death—an...
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Completely new mechanism behind some cancers discovered
By Michael Irving May 09, 2023 Scientists have discovered a new cause of cancer – a mutation in a specific gene that interferes with a cellular cleanup process Depositphotos Cancer can be the end result of a wide range of things that go wrong, and understanding how is key to prevention and treatment. Now, scientists...
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A new mechanism for crossing the blood–brain barrier
by Lori Dajose, California Institute of Technology CA-IV is required for the CNS potency of Car4-dependent AAV. (A) Immunostaining for CA-IV in the brains of WT/WT and KO/KO Car4 mice. Magnified regions from WT/WT demonstrate endothelial expression across diverse brain regions. (B) AAV-PHP.eB, 9P31, and 9P36 packaging mNeonGreen under the control of the ubiquitous CAG promoter...
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Scientists discover a new mechanism to generate cartilage cells
by Forsyth Institute Credit: CC0 Public Domain As any weekend warrior understands, cartilage injuries to joints such as knees, shoulders, and hips can prove extremely painful and debilitating. In addition, conditions that cause cartilage degeneration, like arthritis and temporomandibular joint disorder (TMJ), affect 350 million people in the world and cost the U.S. public health system...
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New mechanism extends life of immune system
by University College London Human chromosomes (grey) capped by telomeres (white). Credit: PD-NASA; PD-USGOV-NASA A new mechanism that slows down and may even prevent the natural aging of immune cells—one of the nine hallmarks of aging—has been identified by an international team led by UCL scientists. Published in Nature Cell Biology, researchers say the discovery in-vitro...
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Researchers identify a new mechanism responsible for controlling auditory sensitivity
by Kelsea Pieters, CU Anschutz Medical Campus Credit: CC0 Public Domain A new study published in PNAS highlights a newly identified mechanism of how auditory sensitivity is regulated that could temporarily reduce sensitivity of the auditory system to protect itself from loud sounds that can cause irreversible damage. The study, led by CU Anschutz researchers Andrew Mecca...
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Researchers find new mechanism to turn on cancer-killing T cells
by University of Chicago Medical Center Scanning electron micrograph of human T lymphocyte or T cell. Credit: NIAID/NIH Over the past decade, researchers have made great strides in the development and administration of cancer immunotherapies, which use the body’s own immune system to treat disease. However, the therapies don’t work for every person or with...