by Ludwig Maximilian University of Munich Pathway synopsis (I.) Sterile inflammation triggers the activation of a subset of cDCs, which respond by releasing CCL17. (II.) In turn, CCL17 binds to CCR8 on cDCs (autocrine) and on CD4+ T cells (paracrine) to stimulate an upregulation of CCL3 expression and release. (III.) Subsequently, CCL3 interacts with CCR1 on...
by Julia Rinner, Technical University Munich Novel image-based flow cytometry enables the identification of cell aggregates and their components. a Scheme of a flow cytometry setup including a DHM and a microfluidic chip. The insert illustrates the applied principle of hydrodynamic focusing in two dimensions. b Study workflow: consisting of admission of patients to the hospital,...
Peer-Reviewed Publication ROCKEFELLER UNIVERSITY Hospital nurseries routinely place soft bands around the tiny wrists of newborns that hold important identifying information such as name, sex, mother, and birth date. Researchers at Rockefeller University are taking the same approach with newborn brain cells—but these neonates will keep their ID tags for life, so that scientists can...
UNIVERSITY OF GALWAY IMAGE: THE PHOTOGRAPHS SHOW MRSA GROWING ON THE SURFACES OF TWO AGAR PLATES, ONE WITHOUT GUANOSINE (LEFT) AND ONE WITH GUANOSINE (RIGHT) ONTO WHICH DISKS SOAKED WITH ANTIBIOTICS HAVE BEEN APPLIED. THE ZONES OF CLEARING AROUND THE ANTIBIOTIC DISKS ARE INDICATIVE OF MRSA KILLING. CREDIT: UNIVERSITY OF GALWAY : Scientists at University of...
How does cancer arise? How does cellular composition influence tumor malignancy? These questions are profound and challenging to answer, but are crucial to understanding the disease and finding the right cure. Now, a German-Danish team led by Matthias Mann has developed a ground-breaking technology called ‘Deep Visual Proteomics’. This method provides researchers and clinicians with a...
By Rich Haridy February 21, 2022 A new technique promises to end the need for refrigeration of vaccines Depositphotos Researchers at Australia’s CSIRO have demonstrated a new way to protect the integrity of vaccines against high temperatures. A proof-of-concept study has shown the method keeping vaccines viable at temperatures up to 37 degrees Celsius for...
by Thomas Olafsen and Elin Doeland, University of Oslo The green colors show healthy mitochondria while the red ones are damaged mitochondria undergoing “clearance” by mitophagy. Credit: Xu-xu Zhuang One in six Norwegians over 80 is affected by Alzheimer’s disease. Numbers are even higher worldwide, and there is still no cure available. Researchers at the...
by Greg Glasgow, CU Anschutz Medical Campus Credit: CC0 Public Domain Not all cancerous tumors are created equal. Some tumors, known as “hot” tumors, show signs of inflammation, which means they are infiltrated with T cells working to fight the cancer. Those tumors are easier to treat, as immunotherapy drugs can then amp up the immune...
by Medical University of Vienna Patients with thyroid dysfunction are routinely treated with drugs to regulate the hormone imbalance. The effect of these drugs is clinically evaluated by means of blood tests. A team led by Michael Krebs from MedUni Vienna’s Division of Endocrinology and Metabolism has now conducted a study to test the use of magnetic resonance...
