OSAKA UNIVERSITY IMAGE: THE INSULIN/IGF SIGNALING PATHWAY PLAYS AN IMPORTANT ROLE IN MANY BIOLOGICAL PROCESSES, SUCH AS ENERGY METABOLISM AND CELL SURVIVAL. SARS-COV-2 INFECTION IMPAIRS TRANSCRIPTIONAL EXPRESSION OF THE INSULIN/IGF SIGNALING PATHWAY IN THE HOST LUNG, LIVER ADIPOSE TISSUE, AND PANCREATIC CELLS, WHICH IS LIKELY ATTRIBUTED TO INTERFERON REGULATORY FACTOR 1 (IRF1). THE PATHOLOGICAL TRAIT...
