by Salk Institute Sperm, pictured inside each round cell, were not generated while mice took the HDAC inhibitor drug (top right), but after 60 days off the drug, spermatogenesis was recovered (bottom right). The left column shows sperm at the same time points in a mouse that did not receive the drug. Credit: Salk InstituteSurveys show...
by Lisa Marshall, University of Colorado at Boulder Graphical abstract. Credit: Molecular Cell (2023). DOI: 10.1016/j.molcel.2023.03.017 CU Boulder researchers have discovered a protein’s crucial role in helping breast and ovarian tumors survive and thrive and have found that suppressing that protein kills cancer cells without harming healthy ones. The findings, published Tuesday, April 12, in the journal Molecular...
by Bill Snyder, Vanderbilt University Medical Center Credit: Unsplash/CC0 Public Domain An international coalition of biomedical researchers co-led by Alexander Bick, MD, Ph.D., at Vanderbilt University Medical Center has determined a new way to measure the growth rate of precancerous clones of blood stem cells that one day could help doctors lower their patients’ risk of blood cancer....
by Medical College of Georgia at Augusta University From left, Qian Ma, PhD, and Yuqing Huo, MD, PhD. Credit: Michael Holahan, Augusta University Soon after cholesterol and fat start depositing on the lining of the blood vessels that supply your heart, the smooth muscle cells that give the blood vessels strength and flexibility start to...
by Ronja Münch, Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie – Hans-Knöll-Institut (Leibniz-HKI) Active centre of the enzyme BurG, which forms a highly reactive chemical compound that plays a crucial role in melioidosis. Credit: Michael Groll/Felix Trottmann Researchers at the Leibniz Institute for Natural Product Research and Infection Biology—Hans Knöll Institute (Leibniz-HKI) in Jena, Germany have identified...
by Will Doss, Northwestern University Credit: Pixabay/CC0 Public Domain An anti-seizure medication acts on unexpected molecular targets, according to a Northwestern Medicine study published in the Journal of Neuroscience. Designed to target AMPA receptors in the brain, the medication—called perampanel—turns out to also modulate kainate receptors, according to Geoffrey Swanson, Ph.D., professor of Pharmacology and senior...
WEILL CORNELL MEDICINE IMAGE: ART1 (IN GREEN) EXPRESSION IN TUMOR TISSUE FROM A LUNG CANCER PATIENT. CREDIT: SUMIT MUKHERJEE Tumors can use an enzyme called ART1 to thwart antitumor immune cells, making the enzyme a promising new target for immunity-boosting cancer treatments, according to a study from researchers at Weill Cornell Medicine and Albert Einstein College...
by Medical College of Wisconsin Credit: Pixabay/CC0 Public Domain Neglected tropical diseases (NTDs) represent a group of about 20 conditions that affect more than a billion people worldwide. They are diseases of poverty that impact people living in the poorest communities in terms of wealth, infrastructure, and access to sanitation. They take health away; and...
by Medical College of Georgia at Augusta University Dr. Meghan McGee-Lawrence. Credit: Michael Holahan, Augusta University Drugs we take like prednisone can weaken our bones and so can aging, and scientists working to prevent both have some of the first evidence that the best target may not be the logical one. They are finding that...
by University of Technology, Sydney Professor Phil Hansbro, Director of the Centenary UTS Centre for Inflammation. Credit: Supplied by Centenary UTS Centre for Inflammation Research led by the Centenary Institute and University of Technology Sydney (UTS) has identified a small RNA molecule called microRNA-21 as a therapeutic target and its inhibition as a potential treatment...
