by Aaron Conley, Vanderbilt University Credit: Unsplash/CC0 Public Domain Vanderbilt researchers found that ketamine’s rapid antidepressant action is due to specific synaptic effects. This represents a new target for drug development that could fill a major gap in care for depression. The research was led by Lisa Monteggia, professor of pharmacology and director of the Vanderbilt...
Blocking a key enzyme could kill parasites that have evolved resistance to existing drugs. Every year, more than 200 million people are infected with malaria, and nearly 500,000 die from the disease. Existing drugs can treat the infection, but the parasite that causes the disease has evolved resistance to many of them. To help overcome...
by WEHI Hallmarks of inflammation. An international team of researchers have uncovered a drug-like compound that blocks a crucial inflammatory pathway, potentially paving the way for a new treatment for a host of diseases—including COVID-19. WEHI’s Associate Professor Seth Masters and his research team discovered the compound could prevent up-regulation of CD14, a key inflammatory protein. The discovery was...
