by Queen Mary, University of London Pressure-driven foam cell formation revealed as key driver of arterial disease, paving the way for new therapiesChronic Yoda1 treatment supports transition to a foam cell phenotype. A-B) Wound scratch assay shows reduced migration of Yoda1 treated A7r5 cells. C) Nanoindentation indicates a lower Young’s Modulus after Yoda1 treatment. D,E)...
Tag: <span>new therapies</span>
Post
Newly discovered genetic mutation protects against Parkinson’s disease and offers hope for new therapies
by University of Southern California Credit: Unsplash/CC0 Public DomainA previously unidentified genetic mutation in a small protein provides significant protection against Parkinson’s disease and offers a new direction for exploring potential treatments, according to a new USC Leonard Davis School of Gerontology study. The variant, located in a mitochondrial microprotein dubbed SHLP2, was found to be...
Post
Researchers identify unique cell receptor, potential for new therapies
by CU Anschutz Medical Campus Credit: Unsplash/CC0 Public Domain Researchers from the University of Colorado Anschutz Medical Campus have identified a potential new immune checkpoint receptor that could lead to treatments for diseases such as lung and bowel cancer and autoimmune conditions including IBD. The study, published today in Science Immunology, examines a family of 13 receptors, or...
Post
Antibody discovery paves way for new therapies against group A streptococcal infections
by Lund University Graphical abstract. Credit: EMBO Molecular Medicine (2022). DOI: 10.15252/emmm.202216208 Researchers at Lund University in Sweden have discovered an antibody with the potential to protect against Strep A infection, as well as a rare form of antibody binding, that leads to an effective immune response against bacteria. The discovery could explain why so many group...
Post
Discovery of new key protein in cell function paves way for new therapies
by Prof. George Garinis, Foundation for Research and Technology – Hellas Credit: Foundation for Research and Technology – Hellas Over time, we accumulate genetic damage that accelerates the aging process, increasing the risk of carcinogenesis. DNA is continually challenged by genotoxic factors that affect its fragile structure, inhibiting cell functions. To meet this challenge, cells have evolved a number of...