by Gillian Rutherford, University of Alberta Mutation burden in the skin of patients with SSc. Skin biopsies were obtained from the distal forearm, the sequencing libraries were prepared from the microdissected areas of fibrosis and analyzed by whole exome sequencing. A: The number of synonymous and non-synonymous mutations in the samples; B: the types of...
by Rebekah McBride, University of Wisconsin-Madison Addition of BMP7 during neuronal differentiation further dorsalizes postmitotic population. (A) Timeline of dorsal differentiation from H120-NMPs, with BMP7 added during neuronal differentiation phase from days 14 to 19. (B to G) Immunostaining in day 19 postmitotic cultures shows that DAPT treatment rapidly converts progenitors to dorsally shifted postmitotic phenotypes...
JON HAMILTON Scientists say research into Alzheimer’s needs to take a broader view of how the disease affects the brain — whether that’s changes in the cortex or the role of inflammation. Matt York/AP The field of Alzheimer’s research is branching out. After decades of focusing on the sticky amyloid plaques and tangled tau fibers...
by Will Doss, Northwestern University High magnification micrograph of Crohn’s disease. Biopsy of esophagus. H&E stain. Credit: Nephron/Wikipedia Two new treatments for Crohn’s disease showed roughly equal performance in a clinical trial, according to findings published in The Lancet. This allows clinicians and patients to make treatment choices based on tolerance, according to Stephen Hanauer, MD, the Clifford...
by CU Anschutz Medical Campus Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. Credit: Wikipedia Currently, there are no disease modifying therapies for Parkinson’s disease that can change the progression of the disease. An international team of scientists led by faculty at the University of...
By Maddie Bender on June 1, 2022 Credit: Thomas Fuchs If pimples are caused by oily skin, why doesn’t a good washing prevent all breakouts? A recent study offers an answer— and maybe a new line of defense. Pimples contain tiny and discrete bacterial infections. The most commonly involved bacteria are Cutibacterium acnes, which live innocuously on skin cells but...
by Johns Hopkins University Bloomberg School of Public Health Credit: Pixabay/CC0 Public Domain A new genetic mapping study led by researchers at the Johns Hopkins Bloomberg School of Public Health traces links between DNA variations and thousands of blood proteins in two large and distinct populations. The results should help researchers better understand the molecular...
UNIVERSITY OF READING Alzheimer’s Disease could be caused by damage to a protective barrier in the body that allows fatty substances to build up in the brain, newly published research argues. A new explanation called the ‘Lipid Invasion Model’, argues that lipids entering the brain due to damage to the blood brain barrier – a dense...
by Rutgers University Credit: CC0 Public Domain New research may help scientists locate immature cells in the central nervous system that could shed light on the causes of neurodegenerative diseases like multiple sclerosis—and autoimmune disease that affects the brain and nervous system—and allow for the development of better therapeutic treatments. In a new study, published...
by Hiroshima University Researchers established stable cell lines producing high-titer cell culture-generated Hepatitis B virus of various genotypes. Credit: Michio Imamura, Hiroshima University Researchers created stable cell lines capable of producing different genotypes of the hepatitis B virus (HBV), advancing understanding of each type’s distinct virological features, treatment responses, and infectivity that could lead to...
