MICHIGAN MEDICINE – UNIVERSITY OF MICHIGAN A long noncoding RNA whose function was previously unknown turns out to play an important role in promoting the body’s immune response against cancer and holds promise for enhancing the efficacy of anti-cancer immunotherapy. That’s according to new findings reported in Nature Cell Biology by researchers at the University of Michigan Rogel Cancer...
Tag: <span>noncoding RNA</span>
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Neural plasticity depends on this long noncoding RNA’s journey from nucleus to synapse
by The Scripps Research Institute Synaptic activation promotes a signaling cascade that results in the expression of long noncoding RNA, ADEPTR. It’s quickly transported along dendrites to synapses, where it acts on proteins involved in remodeling. Credit: Jenna Wingfield and Yibo Zhao of the Puthanveettil lab at Scripps Research in Jupiter, Florida. Making memories involves more than seeing friends or...
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Study identifies noncoding RNA involved in immune response and sepsis
by University of California – Santa Cruz GAPLINC, a highly conserved long noncoding RNA, modulates the immune response during endotoxic shock. Reducing or eliminating GAPLINC led to enhanced expression of inflammatory genes in both mouse and human cells. In a mouse model of sepsis, knockout mice without GAPLINC were protected from endotoxic shock. Credit: Apple Vollmers...