by Nationwide Children’s Hospital Graphical abstract. Credit: Circulation Research (2022). DOI: 10.1161/CIRCRESAHA.122.321398 A new study published in Circulation Research provides novel insights into how mutations in the NOTCH1gene may lead to abnormal differentiation and proliferation of cardiomyocytes and contribute to ventricular hypoplasia and other structural anomalies found in congenital heart defects in humans. In 2005, Vidu Garg, MD, a pediatric cardiologist...
