by Ana María Rodríguez, Baylor College of Medicine Credit: Pixabay/CC0 Public DomainIn 2020, heart failure affected about 6.5 million people in the U.S. and 23 million around the world. Despite recent advances, the five-year survival rate remains approximately 50%, indicating an urgent need for a novel perspective for treating this condition. A new approach described in...
by University Hospitals of Leicester NHS Trust Baseline [18F]FDG-PET-CT and chest radiograph features of incipient tuberculosis. Credit: The Lancet Microbe (2024). DOI: 10.1016/S2666-5247(23)00289-6A novel approach to studying the progression of tuberculosis (TB) from infection to disease has identified and treated people at increased risk of developing the disease that current methods of testing would not.Researchers...
by Tohoku University Osmotic pressure-and-viscosity-modified Docetaxel via lymphatic drug delivery system (LDDS) can inhibit tumor growth in the lymphatic system and prevent distant metastasis. Increases in osmotic pressure and viscosity lead to significant tumor inhibition in the sentinel lymph node (LN) and its’ downstream LN. Moreover, we found the underlying mechanism of increased osmotic pressure and...
by Marcus Neitzert, Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) Credit: Cell (2023). DOI: 10.1016/j.cell.2023.10.001 Researchers at DZNE and Charité–Universitätsmedizin Berlin have pioneered a novel treatment for the most common autoimmune encephalitis. By reprogramming white blood cells to target and eliminate disease-causing cells, the approach offers a new level of precision and efficiency. The technique...
by Ludwig Cancer Research Graphical abstract. Credit: Cell (2022). DOI: 10.1016/j.cell.2022.03.030 Natural killer (NK) cells have lately become a hot focus of efforts to develop new immunotherapies. Researchers led by Ludwig Harvard’s Tony Letai, whose team collaborated closely with the Ludwig Harvard Kai Wucherpfennig lab in this study, reported in an April issue of Cell a potentially novel approach...
by Baylor College of Medicine Credit: Unsplash/CC0 Public Domain Researchers at Baylor College of Medicine and Texas Children’s Hospital have identified potent, highly specific compounds that interfere with bromodomain (BD)-containing proteins involved in cancer. The compounds, called BET BD1-inhibitors, are a starting point in the development of potentially more effective anti-cancer drugs with less side...
by University of Surrey Credit: Unsplash/CC0 Public Domain Findings from a seven-year research project suggests that there could be a new approach to treating one of the most common and devasting forms of brain cancer in adults—Glioblastoma Multiforme (GBM). In a peer-reviewed study published by BMC Cancer, scientists from the University of Surrey show that...
by Trinity College Dublin Brain with Brodmann areas marked. Credit: Patricia Hurl, 1992, (Gouache on paper). Scientists at Trinity College Dublin have announced a significant advance in our understanding of epilepsy, as they have identified a potential method of preventing damaging seizure activity. Epilepsy is a chronic central nervous system (CNS) disorder affecting approximately 1%...
by University of Michigan Credit: Pixabay/CC0 Public Domain While researchers have identified several genes that drive prostate cancer, a new study published in Nature reveals the puppet master controlling the strings. The strings: Cancer-causing genes, or oncogenes, such as androgen receptor, FOXA1, ERG, and MYC. The puppet master: A chromatin remodeling complex called SWI/SNF, which controls the...
by Loyola University Health System Credit: Pixabay/CC0 Public Domain A team of scientists from Loyola University Chicago’s Stritch School of Medicine have discovered a critical component for renewing the heart’s molecular motor, which breaks down in heart failure. Approximately 6.2 million Americans have heart failure, an often fatal condition characterized by the heart’s inability to pump enough blood...
