by Melissa Rohman and Olivia Dimmer, Northwestern University Notch3 deficiency results in vascular dysfunction due to impaired contractility. Immunofluorescence of phosphorylated myosin light chain 2 (pMLC2–red). White arrows highlight alpha-SMA (green), yellow arrows highlight pMLC (red). Credit: Luisa Iruela-Arispe, Ph.D./Northwestern University Decreased activity of a specific signaling pathway in brain vessels was linked to a...
by Texas Children’s Hospital Credit: Cell Metabolism (2023). DOI: 10.1016/j.cmet.2023.03.022 Degeneration of myelin, an insulating sheath required for rapid communication between nerve cells, and neuroinflammation are notable hallmarks of Multiple Sclerosis (MS) and related neurodegenerative disorders such as Alzheimer’s disease and Huntington’s disease, which affect roughly 2.8 million people in the world. However, little is known about...
