by Cristy Lytal, University of Southern California Figure 1. Structure-based design of selective CBX8 compounds. (A) Reported CBX7 compounds and their in vitro potency in an AlphaScreen competition assay. (B) Comparison of the alanine binding pocket size of CBX7 (top) and CBX8 (bottom). (C) Comparison of the aromatic cage region of CBX7 (top) and CBX8 (bottom). (D)...