by City of Hope National Medical Center Type II interferon (IFNy), a substance produced by immune cells, disrupts the leukemia stem cells’ ability to divide and spread cancer. However, IFNy also stimulates CD38, a protein that suppresses the immune cells’ ability to mount a response against infection. To overcome this challenge, City of Hope researchers designed...
by Aaron Nieto, Baylor College of Medicine Prostate cancer cells. Credit: NIH Image Gallery Finding valuable therapeutic interventions for prostate cancer has long guided the research of Dr. Feng Yang’s lab at Baylor College of Medicine. In a study published in the Proceedings of the National Academy of Sciences, Yang’s team took a close look into...
by The Scripps Research Institute Scripps Research scientists have found a protein in immune cells (called neutrophils) that could be a target against harmful inflammation. An imaging technique called Stochastic Optical Reconstruction super-resolution Microscopy (STORM, right image) shows that in resting neutrophils, the WASH protein complex (green) forms a molecular clustered complex with microfilaments called...
THE KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (KAIST) IMAGE: FIGURE. HUNTINGTON’S DISEASE RESISTANCE HUNTINGTIN PROTEIN INDUCED BY ANTISENSE OLIGONUCLEOTIDE (AON) IS RESISTANT TO CASPASE-6 CLEAVAGE, THEREFORE, DOES NOT CAUSE HUNTINGTON’S DISEASE WHILE MAINTAINING NORMAL FUNCTIONS OF HUNTINGTIN. CREDIT: HYEOUNGJUN KIM, ET AL., 2022 Through an international joint research effort involving ProQR Therapeutics of the...
by Li Yuan, Chinese Academy of Sciences Albumin-stabilized emulsion deformation enhances lymph node homing. Credit: IPE Researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences developed deformable albumin-stabilized emulsions that could improve lymph node delivery efficiency and immune response effect, providing a new strategy for the enrichment of vaccines to lymph nodes....
