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How the nucleus accumbens mediates positive and negative motivational valence
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How the nucleus accumbens mediates positive and negative motivational valence

by Li Yuan, Chinese Academy of Sciences Distribution of NAcBLA and NAcPVT neurons in the NAc. Credit: SIAT Reward-seeking and threat avoidance are critical for survival. Pursuing enjoyable things triggers the release of dopamine in the brain, making people feel pleasure. In contrast, people subconsciously avoid unpleasant feelings such as hunger, nausea and pain in order to...

A mechanism by which cells build ‘mini-muscles’ underneath their nucleus identified
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A mechanism by which cells build ‘mini-muscles’ underneath their nucleus identified

UNIVERSITY OF HELSINKI IMAGE: On the left: Super-resolution microscopy image of a migrating human osteosarcoma cell. Magenta marks focal adhesions, and green non-muscle myosin II (NMII). F-actin bundles are shown in grey. On the right: Schematics of cortical stress ?ber assembly process. Myosin II pulse orchestrates the initial assembly and maturation of a cortical stress...

Scientists kill cancer cells by ‘shutting the door’ to the nucleus
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Scientists kill cancer cells by ‘shutting the door’ to the nucleus

SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE IMAGE: MAXIMILIANO D’ANGELO, PH.D., ASSOCIATE PROFESSOR IN THE DEVELOPMENT, AGING AND REGENERATION PROGRAM AT SANFORD BURNHAM PREBYS. Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that blocking the construction of nuclear pores complexes–large channels that control the flow of materials in and out of the cell nucleus–shrank aggressive tumors...