by University of Tsukuba Credit: Cell Reports (2023). DOI: 10.1016/j.celrep.2023.112914 Obesity not only increases the risk of metabolic syndrome-related diseases, such as diabetes, fatty liver, and atherosclerosis, but also remarkably impacts seemingly unrelated conditions, such as cancer, psychiatric disorders, and immune function. To understand this wide range of diseases and develop therapeutic approaches for the...
Linda Geddes I’ve made a cup of coffee, written my to-do list and now I’m wiring up my ear to a device that will send an electrical message to my brainstem. If the testimonials are to believed, incorporating this stimulating habit into my daily routine could help to reduce stress and anxiety, curb inflammation and...
by Lori Solomon Among adults with overweight or obesity, the annual probability of weight loss of 5 percent or more was achieved by only one in 10, according to a study published online Aug. 7 in JAMA Network Open. Lyudmyla Kompaniyets, Ph.D., from the U.S. Centers for Disease Control and Prevention in Atlanta, and colleagues assessed...
Kevin Fernando, MBChB, MSc July 05, 2023 The advent of subcutaneously injectable GLP-1 receptor agonists for the management of type 2 diabetes during 2005 was arguably one of the greatest therapeutic advances for the condition since metformin. I was an early advocate of the class, given its potent glucose-lowering efficacy, secondary benefits of significant weight reduction, and...
By UNIVERSITY OF CALIFORNIA, RIVERSIDE JULY 26, 2023 Scientists have conducted a study using a mouse model to understand sex differences in obesity. They found that female mice, compared to males, are more resistant to obesity and inflammation due to a higher secretion of an immune protein called RELMalpha. The study reveals a crucial ‘RELMalpha–eosinophil–macrophage axis’ in...
By AMSTERDAM UNIVERSITY MEDICAL CENTERS JUNE 18, 2023 New research indicates that brain responses to nutrients are diminished in people with obesity and don’t improve even after weight loss. The study revealed that individuals with obesity released less dopamine in a brain region crucial for food intake motivation, compared to those with healthy body weight. Additionally, obese participants showed...
Marlene Busko June 13, 2023 Could glucagon-like peptide-1 (GLP-1) receptor agonists such as semaglutide — approved as Ozempic to treat type 2 diabetes and as Wegovy to treat obesity, both from Novo Nordisk — also curb addictions and compulsive behaviors? As demand for semaglutide for weight loss grew following approval of Wegovy by the US Food and Drug Administration in 2021, anecdotal reports of...
by Hong Kong Polytechnic University 3D molecular models of ABarginase, albumin and FcRn receptor on a cell surface. Credit: Hong Kong Polytechnic University Researchers from The Hong Kong Polytechnic University (PolyU) and The Chinese University of Hong Kong (CUHK) have jointly made a groundbreaking drug discovery in treating multiple metabolic diseases related to obesity and insulin...
by Jackie Maupin, Indiana University School of Medicine Credit: Unsplash/CC0 Public Domain Indiana University School of Medicine researchers studying clonal hematopoiesis of indeterminate potential (CHIP), a blood condition that may increase the risk of blood cancer, discovered that obesity was strongly associated with the condition. Their findings were recently published in the Journal of Clinical Investigation. CHIP...
by Garvan Institute of Medical Research Researchers have pinpointed a subset of neurons (green) in the arcuate nucleus of the hypothalamus that drive appetite under obesity. Credit: Dr Yue Qi A team at the Garvan Institute of Medical Research has discovered a group of brain cells that boosts appetite when there is a prolonged surplus of energy in the body,...
