by Olivia Dimmer, Northwestern University Octopamine is a calcineurin-dependent metabolite released under α-syn proteotoxicity that mediates Ca2+ influx in astrocytes. (A) Metabolite screen from supernatants of rat primary cortical neuron–astrocyte cocultures transduced with either control lentivirus or α-synA53T driven by the synapsin promoter and treated with either vehicle (DMSO) or subsaturating (0.2 µM) doses of FK506 5 to...
