Written by Nicole E. Cieri-Hutcherson, PharmD, BCPS, NCMP | Reviewed by Nicole Rowe, MD Key takeaways: Omeprazole (Prilosec, Prilosec OTC) is a proton pump inhibitor (PPI). PPIs treat gastrointestinal conditions such as heartburn and gastroesophageal reflux disease.Research shows that PPIs like omeprazole are associated with short-term and long-term kidney damage. But the overall risk is...