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Emerging group of synthetic opioids may be more potent than fentanyl, study warns
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Emerging group of synthetic opioids may be more potent than fentanyl, study warns

By Jacqueline Howard, CNN CNN—A group of novel synthetic opioids emerging in illicit drugs in the United States may be more powerful than fentanyl, 1,000 times more potent than morphine, and may even require more doses of the medication naloxone to reverse an overdose, a new study suggests. A bag of evidence containing the synthetic...

Opioids frequently prescribed to patients with cirrhosis
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Opioids frequently prescribed to patients with cirrhosis

by Elana Gotkine HealthDay Reporter  Opioids are frequently prescribed to patients with cirrhosis, often without a pain diagnosis, according to a research letter published online Dec. 8 in Clinical Gastroenterology and Hepatology. Anna H. Lee, M.D., from the David Geffen School of Medicine at the University of California in Los Angeles, and colleagues conducted a retrospective study...

Opioids and the brain: New insights through epigenetics
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Opioids and the brain: New insights through epigenetics

by Greta Friar, Whitehead Institute for Biomedical Research Credit: Pixabay/CC0 Public Domain Drug overdose, mostly from opioid use, is the leading cause of accidental death in the United States. Prior studies of twins have revealed that genetics play a key role in opioid use disorder. Researchers know that a mixture of genetic and environmental risk...

Opioids provide low evidence of pain relief for migraine
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Opioids provide low evidence of pain relief for migraine

by Adam Harringa  Credit: Sasha Wolff/Wikipedia Evidence that opioids provide pain relief for migraine headaches is low or insufficient, a large Mayo Clinic meta-analysis published recently in JAMA has found. However, some newer therapies, along with established migraine treatments, were associated with moderate to high evidence of pain relief. The meta-analysis – which combined results from multiple scientific studies...

Painkiller-dispensing patch could be an alternative to opioids
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Painkiller-dispensing patch could be an alternative to opioids

By Ben Coxworth January 12, 2021 Potentially addictive opioid painkillers are frequently prescribed to patients recovering from surgery, but a new implantable patch may make them unnecessary wollertz/DepositphotosVIEW 1 IMAGES In order to keep patients from developing opioid addictions, it’s best if doctors can avoid prescribing the things in the first place. A new surgical patch...

Perspective: Why opioids cannot fix chronic pain
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Perspective: Why opioids cannot fix chronic pain

by Bobbi Nodell,  University of Washington Credit: CC0 Public Domain A broken heart is often harder to heal than a broken leg. Now researchers say that a broken heart can contribute to lasting chronic pain. In a reflections column published Dec. 21 in the Annals of Family Medicine, pain experts Mark Sullivan and Jane Ballantyne at the University of Washington School...

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Patients with newly diagnosed musculoskeletal pain are prescribed opioids more often than recommended

During their first physician visit, patients experiencing newly diagnosed chronic musculoskeletal pain are prescribed opioids more often than physical therapy, counseling, and other nonpharmacologic approaches, according to a new study published in the Journal of Pain. The use of opioids over other approaches stands in contrast with clinical recommendations for the use of nonopioid pain...

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Researchers say 30% of patients taking opioids experience adverse drug interactions

Complications often go undetected but can contribute to misuse and overdose, according to The Journal of the American Osteopathic Association AMERICAN OSTEOPATHIC ASSOCIATION CHICAGO–December 10, 2019– Patients who do not disclose use of other medications are at higher risk of adverse drug interactions and addiction, according to new research in The Journal of the American...

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Opioids are not sleep aids, and can actually worsen sleep, research finds

by Alice Scott,  University of Warwick Evidence that taking opioids will help people with chronic pain to sleep better is limited and of poor quality, according to an interdisciplinary team of psychologists and medics from the University of Warwick in partnership with Lausanne University Hospital, Switzerland. Many people suffering from long-term chronic pain use opioids as...

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Historically ‘safer’ tramadol more likely than other opioids to result in prolonged use

MAYO CLINIC ROCHESTER, Minn. — Surgical patients receiving the opioid tramadol have a somewhat higher risk of prolongeduse than those receiving other common opioids, new Mayo Clinic research finds. However, the Drug Enforcement Administration (DEA) classifies tramadol as a Schedule IV controlled substance, meaning it’s considered to have a lower risk of addiction and abuse thanSchedule II opioids, such as oxycodone and hydrocodone. The study was published...

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