Marlene Busko July 24, 2023 Could glucagon-like peptide-1 receptor agonists, such as liraglutide and semaglutide, also be potential disease-modifying treatments for knee osteoarthritis (KOA)? Weight loss is recommended for patients with KOA, and GLP-1 receptor agonists are approved for weight loss. New early research suggests these drugs might have a disease-modifying effect for KOA. Three recently published studies investigated this: The LOSEIT phase 4, randomized controlled...
Tag: <span>osteoarthritis pain</span>
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Mast cell levels may explain sex differences in osteoarthritis pain
HOSPITAL FOR SPECIAL SURGERY Investigators at Hospital for Special Surgery (HSS) have discovered that at the time of total knee replacement, women have significantly increased levels of immune cells called mast cells in synovial tissue surrounding the knee joint than men. Their findings, presented today at the annual meeting of the American College of Rheumatology, ACR...
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Targeting ion channels to manage osteoarthritis pain
by Melissa Rohman, Northwestern University The image depicts two drug receptor sites with the molecular structure of the Nav1.7 channel, and tamoxifen’s attenuation of nociceptor action potentials responsible for transmitting aberrant pain signals. Credit: Northwestern University Therapeutically targeting ion channels in nociceptor neurons may be a promising strategy to manage osteoarthritis pain, according to a...